Rapid Rx Quiz: Omega-3 Fatty Acids

Mary L. Windle, PharmD


August 25, 2022

Recent research indicates that OM3FA supplements increase the risk for atrial fibrillation (AF) independent of other clinical outcomes in a dose-dependent way. Experimental studies have shown that OM3FAs modify cardiac calcium, potassium ionic currents, and sodium activity, thus variably resulting in lengthening or shortening of the ventricular action potential duration. Other than AF, adverse effects reportedly associated with OM3FAs include:

  • Angina pectoris

  • Back pain

  • Dyspepsia

  • Eructation

  • Flu-like syndrome

  • Infection

  • Pain

  • Rash

  • Taste perversion

Postmarketing reports of adverse events associated with OM3FA use also revealed anaphylactic reactions, hemorrhagic diathesis, and urticaria.

Learn more about adverse events and OM3FAs.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.