Fast Five Quiz: Alzheimer's Disease

Helmi L. Lutsep, MD


May 06, 2022

Recent research has shown that posttraumatic amnesia  and chronic vascular lesions caused by traumatic brain injury (TBI) increase risk for subsequent Alzheimer's disease. Evidence also suggests that TBI lowers the age of dementia onset; early-onset Alzheimer's disease has a higher prevalence of TBI.

Other notable differences between early-onset Alzheimer's disease and common late-onset disorder include:

  • Longer delay in diagnosis

  • Decreased cardiovascular fitness

  • Less incidence of diabetes, obesity, circulatory disorders

  • Increased psychosocial problems

  • More aggressive course

  • Greater white matter changes, especially in posterior association areas and frontoparietal networks

Learn more about the presentation of Alzheimer's disease.


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