Fast Five Quiz: Hypothyroidism Practice Essentials

Romesh Khardori, MD, PhD


April 11, 2022

Hashimoto thyroiditis is the most frequent cause of acquired hypothyroidism.

Various medications are also known to potentially cause hypothyroidism. The following medications reportedly have the potential to cause hypothyroidism:

  • Iodinated contrast

  • Amiodarone

  • Interferon alfa

  • Thalidomide

  • Lithium

  • Stavudine

  • Oral tyrosine kinase inhibitors (sunitinib, imatinib)

  • Bexarotene

  • Perchlorate

  • Interleukin (IL)-2

  • Ethionamide

  • Rifampin

  • Phenytoin

  • Carbamazepine

  • Phenobarbital

  • Aminoglutethimide

  • Sulfisoxazole

  • p-Aminosalicylic acid

  • Immune checkpoint inhibitors (ipilimumab, pembrolizumab, nivolumab)

Other causes of acquired hypothyroidism include postpartum thyroiditis, subacute (granulomatous) thyroiditis (also known as de Quervain thyroiditis), and iatrogenic (postsurgical) hypothyroidism.

Learn more about hypothyroidism etiology.


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