Fast Five Quiz: Hypertrophic Cardiomyopathy

Jamshid Shirani, MD


April 13, 2022

In most individuals with HCM, hypertrophy is caused by a genetic mutation, resulting in asymmetric thickening of the ventricular wall, particularly the septum. In 70% of patients diagnosed with HCM, LVOT obstruction is present (pressure gradient, > 30 mmHg). During mid to late systole, systolic anterior motion of the mitral valve results in mitral-septal contact which can increase LVOT obstruction. The severity of LVOT obstruction is dependent on ventricular volume.

Diastolic dysfunction is frequent in patients with HCM. It is caused by left ventricular wall thickening and fibrosis, which leads to impaired ventricular filling and increased left ventricular diastolic pressure. The left ventricle in HCM usually has a normal or elevated ejection fraction.

Learn more about HCM.


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