Fast Five Quiz: Management of Metastatic Bladder Cancer

Kyle A. Richards, MD


March 24, 2022

In 2019, the FDA approved erdafitinib, a tyrosine kinase inhibitor, for metastatic bladder cancer in patients with susceptible FGFR2 or FGFR3 alterations refractory to platinum-based chemotherapy. Studies have demonstrated a 40% response rate that was not affected by the presence of visceral metastasis.

Vascular endothelial growth factor pathway inhibitors do not have an established role in the treatment of metastatic bladder cancer. Although, in clinical trials, ramucirumab and bevacizumab demonstrated improvement in progression-free survival; no improvement in overall survival was noted. Optimal sequencing and potential combinations of available agents are the subject of many ongoing trials.

Learn more about metastatic bladder cancer management.

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