Many patients who are diagnosed with bladder cancer are older, with multiple comorbidities. This makes cisplatin-containing therapy challenging because of the increased risk for toxicities: nephrotoxicity, worsening nausea and vomiting, significant neurotoxicity, myelosuppression, ototoxicity, and neuropathy.
Approximately 50% of patients are not fit for cisplatin therapy; low renal function and poor Eastern Cooperative Oncology Group (ECOG) performance status are the most common causes, according to Srikala S. Sridhar.
According to the Galsky criteria, unfit patients meet at least one of these criteria:
ECOG performance status ≥ 2
Creatine clearance ≤ 60 mL/min
Hearing loss grade ≥ 2
Neuropathy grade ≥ 2
New York Heart Association class 3 heart failure
Learn more about metastatic bladder cancer management.
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Cite this: Kyle A. Richards. Fast Five Quiz: Management of Metastatic Bladder Cancer - Medscape - Mar 24, 2022.