Fast Five Quiz: Type 2 Diabetes and Hypertension

Romesh Khardori, MD, PhD


February 22, 2022

In major observational studies mostly from Japan and from Western countries, approximately 50% of patients with type 2 diabetes had hypertension and 20% of patients with hypertension had type 2 diabetes. Individuals with type 2 diabetes are twice as likely to have hypertension as those without diabetes. Comorbid type 2 diabetes and hypertension increase the risk for both macrovascular and microvascular events.

Although type 2 diabetes has been shown to be causal for hypertension development, the same has not been proven for the reverse relationship; however, the causal effect is small and not likely to be clinically meaningful. Hyperinsulinemia, arterial stiffness, renal dysfunction, and hyperglycemia can contribute to the development of hypertension, whereas hyperinsulinemia, abdominal adiposity, inflammation, and the class of antihypertensive drugs are probably more relevant than hypertension itself in the development of type 2 diabetes.

Learn more about the impact of type 2 diabetes.


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