According to ACG guidelines, a presumptive diagnosis of GERD can be made in the setting of typical symptoms of heartburn and regurgitation. Empirical medical therapy with a PPI is recommended in this setting.
Barium radiography should not be used to diagnose GERD. Upper endoscopy is not required in the presence of typical GERD symptoms. Endoscopy is recommended in the presence of alarm symptoms and for screening patients at high risk for complications. Routine biopsy of tissue from the distal esophagus is not recommended specifically to diagnose GERD.
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Cite this: B.S. Anand. Fast Five Quiz: Gastroesophageal Reflux Disease (GERD) - Medscape - Jul 29, 2021.