Treatment-resistant depression (TRD) is a complex, multifactorial, and biologically heterogeneous disorder with debilitating outcomes. It is usually defined as inadequate response to at least two classes of antidepressant pharmacotherapy at optimum dosages. Estimates suggest at least one third of patients with major depressive disorder (MDD) have TRD. Comorbid anxiety disorder, higher suicide risk, melancholic features, and a lack of response to an initial antidepressant, in addition to a body mass index ≥ 30 kg/m2, a depressive episode lasting > 2 months, being in psychotherapy, sexual dysfunction, and greater depression severity, have all been associated with TRD. TRD results in a substantial burden on both patients and society beyond that posed by MDD alone. Strategies for the management of TRD include pharmacologic augmentation, somatic therapies, psychotherapeutic approaches, as well as various novel approaches.
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Cite this: Ravinder N. Bhalla. Fast Five Quiz: Treatment-Resistant Depression - Medscape - Aug 19, 2021.