Among patients with chronic migraine with allodynia, a randomized controlled trial from 2013 found that an anticonvulsant (divalproex) and a tricyclic antidepressant (amitriptyline) were equally effective as prophylactic therapy for relieving allodynia. The presence of allodynia was shown to be related to female sex as well as the duration, severity, and frequency of migraine.
Learn more about preventive therapies for migraine.
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Cite this: Stephanie J. Nahas, Helmi L. Lutsep. Fast Five Quiz: Chronic Migraine Prevention - Medscape - Feb 04, 2022.