As with abortive medications, the choice of a preventive medication for patients with chronic migraine must include consideration of comorbid conditions and the side-effect profile. Beta-blockers are among the first-line agents for migraine prophylaxis, and two are approved by the US Food and Drug Administration (FDA) for migraine prevention (propranolol and timolol). However, beta-blockers should not be used as a first-line agent for patients over 60 years who smoke. Other first-line agents include tricyclic antidepressants (not FDA-approved) and two anticonvulsants, divalproex sodium and topiramate (both FDA-approved). The only therapy FDA-approved specifically for prevention of chronic migraine is onabotulinumtoxinA.
Learn more about the management of chronic migraine.
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Cite this: Stephanie J. Nahas, Helmi L. Lutsep. Fast Five Quiz: Chronic Migraine Prevention - Medscape - Feb 04, 2022.
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