Fast Five Quiz: Painful Sexual Intercourse

Bradley Schwartz, DO; Michel E. Rivlin, MD


May 21, 2021

The rate of Peyronie disease is difficult to assess because of the embarrassment that many men feel about having this condition. Underreporting may also result from men whose symptoms are mild or nondebilitating and thus do not seek medical attention. The condition usually affects men aged 40-70 years.

Usta and colleagues found that the presence of diabetes, hyperlipidemia, hypercholesteremia, or hypertension was not statistically related to the severity of penile curvature in men with Peyronie disease. The number of comorbidities also did not affect the degree of curvature.

Penile pain almost always resolves without therapy, and this has led to controversy in assessing therapeutic outcomes. Alternatively, some patients note pain in the penis that may subside before the appearance of a palpable plaque or of penile angulation. A less common manifestation is a palpable plaque with no associated pain or angulation.

For practical purposes, Peyronie disease can be divided into acute and chronic phases. The acute phase usually lasts for the first 18-24 months and is characterized by a changing inflammatory pattern that may include penile pain, some curvature, and a penile nodule. The chronic phase is characterized by a stable plaque, often with calcification, and penile angulation. Loss of erectile ability is associated more often with the chronic phase.

Read more about Peyronie disease.