Fast Five Quiz: Breast Cancer Myths

Pavani Chalasani, MD, MPH

Disclosures

April 20, 2021

In the arena of advanced breast cancer, resistance to endocrine therapy remains a significant clinical challenge. One suggested approach to overcome resistance is to block the overacetylation of histones. In preclinical studies, this method helped to overcome resistance to aromatase inhibitors in letrozole-resistant mouse models. However, in a phase 3 trial, the HDAC inhibitor entinostat failed to overcome resistance to endocrine therapy in HR-positive, HER2-negative advanced breast cancer.

As reported at the 2020 San Antonio Breast Cancer Symposium, the study showed no difference in response, progression-free survival, or overall survival whether entinostat was added to exemestane or exemestane was given with placebo. Experts concluded that using a different aromatase inhibitor is unlikely to change outcomes.

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