Fast Five Quiz: Omega-3 Fatty Acids (Fish Oil)

Mary L. Windle, PharmD


April 09, 2021

Fish oil supplements may interact with other medications, especially when taken at higher doses. Although less potent than aspirin, fish oil has been recognized as having antiplatelet effects when large amounts are taken. The supplements may prolong clotting times in patients who are also taking warfarin. However, 3-6 g/d of fish oil is not likely to significantly affect bleeding risk. Although the US Food and Drug Administration–approved package inserts for omega-3 pharmaceuticals suggest that clinically significant bleeding episodes have not been well documented, they also state that patients who take fish oil with anticoagulants should be monitored.

Read more about medications that may interact with fish oil supplements.


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