Fast Five Quiz: COVID-Related Conditions

Michael Stuart Bronze, MD; Vecihi Batuman, MD; Arlen D. Meyers, MD, MBA; Stephen Soreff, MD; Helmi L Lutsep, MD


March 16, 2021

Patients with or recovering from COVID-19 may demonstrate symptoms of major depressive disorder, such as significant weight change or appetite disturbance. However, for diagnosis, DSM-5 criteria specify that the symptoms must not be the result of a medical condition.

For diagnosis of a major depressive disorder, at least five of the following criteria have to be present (and not caused by a medical condition) during the same 2-week period (and at least one of the symptoms must be diminished interest/pleasure or depressed mood):

  • Depressed mood: For children and adolescents, this can also be an irritable mood

  • Diminished interest or loss of pleasure in almost all activities (anhedonia)

  • Significant weight change or appetite disturbance: For children, this can be failure to achieve expected weight gain

  • Sleep disturbance (insomnia or hypersomnia)

  • Psychomotor agitation or retardation

  • Fatigue or loss of energy

  • Feelings of worthlessness

  • Diminished ability to think or concentrate; indecisiveness

  • Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, a suicide attempt, or a specific plan for committing suicide

Read more about the clinical presentation of depression.

This Fast Five Quiz was excerpted and adapted from the Medscape Drugs & Diseases articles Coronavirus Disease 2019 (COVID-19), Acute Kidney Injury, Disorders of Taste and Smell, Depression, and Insomnia.

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