Fast Five Quiz: Tardive Dyskinesia Risk Factors

Christoph U. Correll, MD


February 22, 2021

Perlecan gene, also known as HSPG2 gene, has shown promise as a novel candidate gene for TD research. A 2010 study reported a significant association between HSPG2 gene and TD in Japanese patients with schizophrenia, and this association has been confirmed in other studies.

TD has been associated with polymorphisms of dopamine D3 receptor Ser9Gly and serotonin 2A and 2C receptor genes. While the study of these genes is promising, they have not been shown to be the specific genetic cause of TD; therefore, further research is needed.

While it has been hypothesized that a functional polymorphism of the gene encoding human glutathione S-transferase P1 (GSTP1) might be involved in TD, this gene does not appear to be associated with TD.

Learn more about the differential diagnosis of TD.

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