Fast Five Quiz: Alzheimer's Disease Workup

Jasvinder P. Chawla, MD, MBA


February 22, 2022

Genotyping for APOE alleles has been helpful in determining the risk for AD in patient populations, but consensus statements advise against using APOE genotyping for predicting AD risk.

Plasma levels of APOE *E4 have been associated with dementia risk, independent of the APOE genotype. The risk for AD increased with decreasing levels of APOE levels, with a highly significant threefold increased risk in patients with the lowest tertile of APOE levels relative to the highest tertile. This association remained constant even after adjusting for the APOE genotype. The APOE genotypes associated with highest risk for AD were epsilon 43 and epsilon 44, and those associated with the lowest risks were epsilon 22, epsilon 32, epsilon 42, and epsilon 33.

Learn more about genotyping in AD.


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