Fast Five Quiz: Sinusitis With Nasal Polyps

Arlen D. Meyers, MD, MBA


June 18, 2021

Figure 2. Maxillary sinusitis, CT Scan.

CRSwNP is associated with increased rates of Staphylococcus aureus colonization in the upper airway, which in turn leads to biofilm formation, immune dysregulation, inflammation, and barrier dysfunction, all of which contribute to recalcitrant disease.

Mucosal biofilms are organized communities of bacteria that are enclosed in an exopolymeric matrix composed of water, polysaccharides, nucleic acids, and proteins. They are found in CRS with and without nasal polyps and appear to contribute to the continual, refractory nature of the disease. These biofilms have been associated with tremendous resistance to host defense mechanisms as well as medical therapy.

Bilateral eosinophilic CRSwNP is often connected with nonallergic asthma and intolerance to NSAIDs. Studies suggest that up to 65% and 26% of patients with CRSwNP have comorbid asthma and NSAID-ERD, respectively.

Learn more about the pathophysiology and epidemiology of CRSwNP.


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