Fast Five Quiz: Type 2 Diabetes and Heart Failure

Romesh Khardori, MD, PhD

Disclosures

July 15, 2021

SGLT2 inhibitors may be an effective option for patients with diabetes who are at high risk for heart failure or who already have heart failure. They are the first class of glucose-lowering agents associated with a reduced risk of developing heart failure in patients with diabetes and a reduced risk for hospitalization from heart failure. Multiple trials are underway to test SGLT2 inhibitors as a treatment for heart failure in patients with or without diabetes.

There is currently no evidence that DPP-4 inhibitors can offer cardiovascular benefit.

Thiazolidinedione drugs are not recommended for patients with pre-existing heart failure. In addition, for patients who have diabetes but not heart failure, the use of thiazolidinedione drugs may actually compound the risk for heart failure events.

GLP-1 receptor agonists had no influence on the risk for heart failure hospitalization in patients with diabetes large clinical trials, suggesting that these agents are safe to use among this patient population but are not an effective heart failure prevention strategy.

For additional information, refer to the following clinical practice guidelines:

  • 2021 American Diabetes Association (ADA) Standards of Medical Care in Diabetes

  • 2019 European Society of Cardiology (ESC) Clinical Practice Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases Developed in Collaboration with the European Association for the Study of Diabetes (EASD)

  • 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

  • 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America

  • 2021 ACC/AHA Key Data Elements and Definitions for Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Heart Failure)

  • European Society of Cardiology (ESC) Acute and Chronic Heart Failure Guidelines

Learn more about the treatment for heart failure.

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