Fast Five Quiz: Type 2 Diabetes and Heart Failure

Romesh Khardori, MD, PhD

Disclosures

July 15, 2021

In patients with diabetes, poor glycemic control elevates the risk of developing heart failure. Among this high-risk population, each 1% rise in A1c worsens the risk for incident heart failure by 8%-36%. The mechanisms underlying diabetes and heart failure overlap, so therapeutic strategies that control circulating levels of glucose and fatty acids might prevent or slow the development of heart failure.

In the Framingham Heart Study, diabetes was associated with a nearly twofold increase in the risk for incident heart failure in men and a fourfold increase in women, even after adjusting for other cardiovascular risk factors.

In patients with diabetes, these are some of the factors that amplify the risk for heart failure:

  • Increased age

  • Longer duration of diabetes

  • Hypertension

  • Coronary artery disease

  • Peripheral arterial disease

  • Nephropathy

  • Retinopathy

  • Obesity

  • Higher N-terminal pro–B-type natriuretic peptide (NT-proBNP)

Learn more about reaching a consensus on managing CVD risk in type 2 diabetes.

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