Fast Five Quiz: COVID-19 Clinical Keys

Michael Stuart Bronze, MD


October 22, 2020

Risk factors for severe COVID-19, regardless of age, include the following: 

  • Obesity (body mass index ≥ 30 kg/m2)

  • Chronic kidney disease

  • Chronic obstructive pulmonary disease (COPD)

  • Immunocompromised state due to solid organ transplant

  • Serious heart conditions (eg, heart failure, coronary artery disease, cardiomyopathies)

  • Sickle cell disease

  • Type 1 diabetes mellitus

  • Type 2 diabetes mellitus

The following are underlying conditions that may represent an increased risk for severe COVID-19:

  • Asthma (moderate to severe)

  • Cerebrovascular disease

  • Cystic fibrosis

  • Immunocompromised state due to blood or bone marrow transplant, immunodeficiencies, HIV infection, corticosteroid use (or other medications that weaken the immune system)

  • Neurologic conditions (eg, dementia)

  • Liver disease

  • Pregnancy

  • Pulmonary fibrosis

  • Smoking

  • Thalassemia

Recent studies have shown that the association between the use of ibuprofen or other nonsteroidal anti-inflammatory drugs and increased risk for severe COVID-19 is not well supported. Studies have also not shown an increased risk for severe COVID-19 associated with inflammatory bowel disease. Initial results of a survey of patients with sarcoidosis, a chronic respiratory illness, found that data showed no obvious sign of worse outcomes from COVID-19.

Read more about severe illness in patients with COVID-19.


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