There are four approaches to the prevention and treatment of opioid-induced constipation: (1) over-the-counter agents or agents approved for the treatment of chronic constipation (linaclotide, prucalopride, and lubiprostone, the latter being approved for the treatment of opioid-induced constipation in patients with chronic, noncancer pain); (2) use of alternative opioids, such as tapentadol; (3) use of a fixed combination of opioid and opioid antagonist such as oxycodone-naloxone; and finally, (4) use of PAMORAs (methylnaltrexone, naloxegol, naldemedine). A recent meta-analysis found that approved doses of PAMORAs confer greater therapeutic response and fewer adverse effects in opioid-induced constipation than all of the three other approaches.
Learn more about the prevention and treatment of opioid-induced constipation.
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Cite this: B.S. Anand. Fast Five Quiz: Opioid-Induced Constipation - Medscape - Oct 15, 2020.