Fast Five Quiz: Type 2 Diabetes Key Aspects

Romesh Khardori, MD, PhD

Disclosures

January 21, 2022

According to the ADA, criteria for the diagnosis of diabetes includes any of the following:

  • A fasting plasma glucose level greater than or equal to 126 mg/dL (7 mmol/L); fasting is defined as no caloric intake for at least 8 hours

  • A 2-hour plasma glucose level greater than or equal to 200 mg/dL (11.1 mmol/L) or during a 75-g oral glucose tolerance test

  • An A1c level greater than or equal to 6.5% (≥ 48 mmol/mol)

  • A random plasma glucose level greater than or equal to 200 mg/dL (11.1 mmol/L) in a patient with classic symptoms of hyperglycemia or hyperglycemic crisis

Measuring concentrations of insulin or C-peptide (a fragment of proinsulin that serves as a marker for insulin secretion) is rarely necessary to diagnose T2D or differentiate T2D from T1D. Insulin levels generally are high early in the course of T2D and gradually wane over time. A fasting C-peptide level greater than 1 ng/dL in a patient who has had diabetes for more than 1-2 years is suggestive of T2D (ie, residual beta-cell function).

Learn more about the workup of T2D.

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