Fast Five Quiz: Systemic Treatments for Plaque Psoriasis

Chris G. Adigun, MD; William James, MD


December 21, 2021

Phototherapy is typically reserved for patients with extensive and widespread disease (generally practically defined as more lesions than can be easily counted). However, resistance to topical therapies is another indication for phototherapy.

Biologic and immunomodulatory therapies can be considered for patients with active psoriatic arthritis, as well as for those with more severe or intractable disease.

Most international guidelines suggest that combined topical/systemic therapy may be needed to achieve optimal response in patients with plaque psoriasis as opposed to systemic therapy alone. Studies have shown that significant, clinically meaningful improvement in plaque psoriasis can be achieved with this approach.

The avoidance of specific antihypertensive medications (beta-blockers, calcium-channel blockers, or others) in patients with psoriasis is not generally supported by available evidence. It should be noted, however, that certain medications for psoriasis may trigger or worsen hypertension.

Learn more about systemic therapies for plaque psoriasis.


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