Fast Five Quiz: Exocrine Pancreatic Insufficiency Presentation and Diagnosis

B.S. Anand, MD


May 04, 2020

Exocrine pancreatic insufficiency can be caused by various pancreatic and nonpancreatic diseases with differing mechanisms. Among them, Zollinger-Ellison syndrome, characterized by the tumor called gastrinoma that leads to the inactivation of pancreatic enzymes via increased gastric acid.

Hereditary hemochromatosis can also be a cause of exocrine pancreatic insufficiency due to iron deposition in the pancreas.

Decreased secretion of pancreatic enzymes can occur following pancreatic resection. Decreased hormonal stimulation, rapid transit, and inadequate mixing of chyme with pancreatic enzymes may result from gastric resection.

In chronic pancreatitis, the damage of ducts and parenchyma that leads to exocrine pancreatic insufficiency is permanent.

Learn more about the causes and diagnosis of exocrine pancreatic insufficiency.


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