Fast Five Quiz: Chronic Lymphocytic Leukemia Differential Diagnosis

Karl J. D'Silva, MD


March 09, 2020

Figure 1. CLL viewed under a scanning electron microscope

CLL and MCL are both considered cancers of the small to medium-sized lymphocytes and have some similarities by immunohistochemistry and presentation. A significant difference is that expression of CD20 is dim in CLL, whereas it is bright in MCL. Moreover, MCL typically expresses FMC-7, as well as CD5 and CD19 antigen, but not CD23. Clinically, the two diseases may have a similar presentation; however, MCL is more aggressive than CLL.

Learn more about diagnostic considerations in CLL.


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