Fast Five Quiz: Severe Asthma

Zab Mosenifar, MD


March 18, 2020

According to the GINA report, a sputum eosinophil count ≥ 2% is one of several indicators that a patient who is taking high-dose ICS or daily OCS may have type 2 inflammation. The other signs of possible type 2 inflammation include:

  • Blood eosinophil count ≥ 150/μL

  • Fractional exhaled nitric oxide (FeNO) level ≥ 25 parts per billion

  • Asthma that is clinically allergen driven

  • Patients requiring maintenance OCS therapy (although biomarkers of type 2 inflammation such as blood eosinophil count, sputum eosinophil count, and FeNO level are often suppressed by OCS)

For more on the GINA 2019 update on severe asthma, refer to Part E of the report, beginning on page 84.


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