Skill Checkup: Knee Injection

Dean H. Hommer, MD


October 28, 2019

Intra-articular knee injections of hyaluronic acid have been shown to provide functional and perceived benefits in knee osteoarthritis for up to 5-6 months. Such injections have also been shown to be helpful in patients with knees that are both rheumatoid arthritic and osteoarthritic. PRP injections have shown greater and longer-term efficacy than hyaluronic acid injections in reducing pain and symptoms and improving articular function.

Relative contraindications to PRP knee injections include the following:

  • Regular NSAID use within 48 hours of the procedure

  • Corticosteroid injection of the knee within 1 month or systemic corticosteroid use within 2 weeks

  • Recent fever or illness

  • Cancer, particularly of bone or blood

  • Anemia, with a hemoglobin level lower than 10 g/dL

  • Thrombocytopenia, with a platelet count lower than 105/μL

This Skill Checkup was excerpted and adapted from the Medscape Drugs & Diseases article Knee Injections.

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