Fast Five Quiz: Severe Psoriasis

Dirk M. Elston, MD; William D. James, MD


December 20, 2021

When switching biologics because of a lack of efficacy, no washout period is recommended; however, when switching biologics for a safety reason, a treatment-free interval may be required.

Methotrexate may be used for the management of moderate to severe psoriasis, as long as it remains effective and well tolerated. Combination therapy is another option that may be helpful.

Cyclosporine is generally recommended for intermittent use to induce a clinical response, consisting of one or several courses over a 3- to 6-month period.

Learn more about treatment recommendations for moderate to severe psoriasis.


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