The 18F-NaF PET/CT scan is so sensitive that benign activity may be misinterpreted as bone metastases. Although the 18F-NaF PET/CT scan provides a high-resolution scan with a higher sensitivity and specificity than PET scanning, it can detect benign lesions that may be misinterpreted as malignant.
The sensitivity of 18F-NaF PET/CT scan is sufficient to detect early bone metastases.
The results of an 18F-NaF PET/CT scan do not require comparison with an MRI study to ensure accurate results.
Although the radiation dose of the CT portion of the scan is low, there is an increased total effective radiation dose (overall long-term radiation risk) with the 18F-NaF PE/CT scan. Although the CT scan takes longer to read because of the greater sensitivity of the test, there is sufficient radiation to provide accurate results.
For more on the role of 18F-NaF PET/CT studies in MBD, read here.
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Cite this: Maurie Markman. Fast Five Quiz: Imaging Studies in Metastatic Bone Disease - Medscape - Mar 27, 2019.