The negative effects of high-dose caffeine consumption are seen primarily in a small group of individuals who are caffeine-sensitive. Caffeine has a half-life in plasma of 3-7 hours; this increases approximately twofold in women who are in the later stages of pregnancy or are long-term users of oral contraceptive steroids. Withdrawal symptoms do not relate to the quantity of caffeine ingested daily. For example, Strain and colleagues showed that withdrawal symptoms occur in individuals consuming 129-2548 mg/day of caffeine.
Animal studies and case reports indicate that acute caffeine exposure may induce seizures, whereas chronic exposure might have an opposite effect. Samsonsen and colleagues found no difference between the intake of caffeine 24 hours prior to seizure and the habitual consumption or the consumption on a seizure-free day. In essence, caffeine does not appear to be a common seizure precipitant.
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Cite this: Yasmine S. Ali. Fast Five Quiz: Chocolate and Health Facts vs Fiction - Medscape - Oct 11, 2021.