Fast Five Quiz: Test Your Knowledge of the Diagnosis and Treatment of Locally Advanced, Unresectable Pancreatic Cancer

Michael J. Pishvaian, MD, PhD


September 26, 2018

ASCO guidelines for locally advanced, unresectable pancreatic cancer specify that a palliative care referral should occur as early as possible, ideally at the first visit.

Multiphase CT scanning should include the chest, abdomen, and pelvis. Other staging studies should be based on symptoms. Patients should also be assessed for baseline performance status, symptom burden, and comorbidities, and clinicians again should discuss the goals of treatment in collaboration with a multidisciplinary team shaped by patient preferences. Every patient should be given information about clinical trials.

Initial treatment should include some form of combination regimen for individuals who have a performance status of 0 or 1, have a favorable comorbidity profile, and want to and are able to undergo an aggressive medical regimen. There is no clear evidence to support one regimen over another and therapy may be offered on the basis of extrapolation from data derived from studies in the metastatic setting.

Read ASCO's 2016 Clinical Practice Guideline on locally advanced unresectable pancreatic cancer here and here.


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