According to guidelines from the Centers for Disease Control and Prevention (CDC), watchful waiting is encouraged in uncomplicated cases. Macrolides (eg, azithromycin, fidaxomicin) are not recommended because resistance in Streptococcus pneumoniae has reached approximately 40%. First-line therapy is typically amoxicillin or amoxicillin/clavulanate. However, 90%-98% of rhinosinusitis cases are viral, meaning that antibiotics are not effective. Even in cases when the causative agent is bacterial, antibiotics may not be helpful.
For more on rhinosinusitis, read here.
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Cite this: Mary L. Windle. Fast Five Quiz: Do You Know Best Practices for Antibiotic Use in Respiratory Tract Infections? - Medscape - Dec 06, 2016.