Antibiotic therapy for impetigo may be with a topical agent alone, or a combination of systemic and topical agents. Topical antibiotic therapy is considered the treatment of choice for individuals with uncomplicated localized impetigo. Topical therapy eradicates isolated disease and limits person-to-person spread. Good hygiene with antibacterial washes, such as chlorhexidine or sodium hypochlorite baths, may prevent transmission of impetigo and prevent recurrences, but the efficacy of this has not been proven.
Topical mupirocin or retapamulin is adequate treatment for single lesions of nonbullous impetigo or small areas of involvement. Systemic antibiotics are indicated for nonbullous impetigo with extensive involvement; among athletic teams, childcare clusters, and multiple family members; or for bullous impetigo.
For more on the treatment of impetigo, read here.
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Cite this: William James. Fast Five Quiz: How Much Do You Know About These Common Rashes? - Medscape - Nov 16, 2016.