Fast Five Quiz: How Much Do You Know About Chronic Myelogenous Leukemia?

Emmanuel C. Besa, MD

Disclosures

August 15, 2016

Poor-prognosis characteristics include the following clinical and laboratory factors:

  • Older age

  • Symptomatic presentation

  • Poor performance status

  • African American descent

  • Hepatomegaly

  • Splenomegaly

  • Negative Ph chromosome or BCR/ABL

  • Anemia

  • Thrombocytopenia

  • Thrombocytosis

  • Decreased megakaryocytes

  • Basophilia

  • Myelofibrosis (increased reticulin or collagen)

Approximately 85% of cases are diagnosed in the chronic phase and then progress to the accelerated and blast phases after 3-5 years. CML accounts for 20% of all leukemias affecting adults. It typically affects middle-aged persons. The American Cancer Society estimates that 8220 new cases of CML will be diagnosed in 2016: 4610 in males and 3610 in females.

For more on the background of CML, read here.

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