Fast Five Quiz: What Do You Know About Meningitis?

Michael Stuart Bronze, MD


May 06, 2021

Bacterial resistance, especially penicillin resistance among S pneumoniae strains, has been increasing worldwide. In March 2008, the US Food and Drug Administration revised the susceptibility breakpoints for penicillin versus S pneumoniae. For nonmeningeal infections, the breakpoints are as follows:

  • < 2 µg/mL: Susceptible

  • 4 µg/mL: Intermediate

  • > 8 µg/mL: Resistant

For meningitis, the breakpoints are as follows:

  • < 0.06 µg/mL: Susceptible

  • ≥ 0.12 µg/mL: Resistant

With this meningitis criteria (≥ 0.12 µg/mL), the prevalence of resistance was 34.8% in 2008, whereas with the old criteria (≥ 2 μg/mL) it was 12.3% for CSF.

Learn more about the treatment for meningitis.


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