Urgent replacement of blood is often required for symptomatic anemia due to parvovirus B19 infection or acute splenic sequestration. Transfusions are not needed for asymptomatic chronic anemia or worsening anemia occurring during episodes of pain associated with SCD.
According to NHLBI guidelines, scenarios in which transfusion should be considered include acute chest syndrome or severe exacerbation of anemia with splenic or hepatic sequestration, during severe acute complications such as multi–organ failure syndrome, prior to elective surgery, and in patients at high risk for stroke.
Learn more about the treatment and management of SCD.
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Cite this: Emmanuel C. Besa, Sophie M. Lanzkron. Fast Five Quiz: Are You Prepared to Confront Sickle Cell Disease? - Medscape - Sep 23, 2021.