The selection of pharmacologic treatment remains symptom directed. Agents used for management of symptoms in IBS include anticholinergics, antidiarrheals, tricyclic antidepressants, prokinetics, bulk-forming laxatives, serotonin receptor antagonists, chloride channel activators, and guanylate cyclase C (GC-C) agonists.
A Cochrane systematic review found that several antispasmodics, including peppermint oil, pinaverium, trimebutine, and cimetropium/dicyclomine, significantly outperformed placebo in improving IBS symptom and global assessment scores.
The American College of Gastroenterology's Task Force on the Management of Functional Bowel Disorders noted that the antidiarrheal agent loperamide effectively reduced stool frequency and improved stool consistency, but it did not relieve pain, bloating, or other global IBS symptoms.
For more on the treatment of IBS, read here.
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Cite this: Jamie Shalkow, Jenifer K. Lehrer. Fast Five Quiz: How Much Do You Know About Irritable Bowel Syndrome? - Medscape - Apr 27, 2015.