Fast Five Quiz: Can You Identify Psoriatic Arthritis and Initiate the Best Treatment Practices?

Herbert S Diamond, MD; Anwar Al Hammadi, MD


July 14, 2021

Extra-articular features are observed less frequently in patients with PsA than in those with rheumatoid arthritis (RA); nonetheless, ocular complications are common in patients with PsA. Ocular involvement may occur in 30% of patients with PsA, including conjunctivitis in 20% of patients and acute anterior uveitis in 7%. In patients with uveitis, 43% have sacroiliitis and 40% are HLA-B27–positive. Scleritis and keratoconjunctivitis sicca are rare. Possible ocular findings also include iritis.

Subcutaneous nodules are rare in patients with PsA. If nodules are present in a patient who has psoriasis and arthritis, particularly if the rheumatoid factor titer is positive, they suggest the coincidental occurrence of psoriasis and RA.

Inflammation of the aortic valve root, which may lead to insufficiency, has been described in a small number of patients with PsA and is similar to that observed more frequently in persons with ankylosing spondylitis or reactive arthritis. Rarely, patients with PsA may develop secondary amyloidosis.

Learn more about extra-articular features in PsA.


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