ketotifen, ophthalmic (OTC)

Brand and Other Names:Zaditor, Alaway, more...Zyrtec Itchy Eye Drops
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.025% (equivalent to ketotifen fumarate 0.035%)

Allergic Conjunctivitis

1 gtt in affected eye(s) q8-12hr

Not to exceed 2 doses/day

Dosage Forms & Strengths

ophthalmic solution

  • 0.025% (equivalent to ketotifen fumarate 0.035%)

Allergic Conjunctivitis

<3 years: Safety and efficacy not established

≥3 years: 1 gtt in affected eye(s) q8-12hr; not typically recommended

Not to exceed 2 doses/day

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Interactions

Interaction Checker

and ketotifen, ophthalmic

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                Monitor Closely (189)

                • acarbose

                  ketotifen, ophthalmic, acarbose. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • albuterol

                  ketotifen, ophthalmic increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • alfentanil

                  alfentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • alprazolam

                  alprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • amitriptyline

                  amitriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • amobarbital

                  amobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • amoxapine

                  amoxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • apomorphine

                  apomorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • arformoterol

                  ketotifen, ophthalmic increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • aripiprazole

                  aripiprazole and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • armodafinil

                  ketotifen, ophthalmic increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • azelastine

                  azelastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • baclofen

                  baclofen and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • belladonna and opium

                  belladonna and opium and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • benperidol

                  benperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • benzphetamine

                  ketotifen, ophthalmic increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • brompheniramine

                  brompheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • buprenorphine

                  buprenorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • buprenorphine buccal

                  buprenorphine buccal and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • butabarbital

                  butabarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • butalbital

                  butalbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • butorphanol

                  butorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • caffeine

                  ketotifen, ophthalmic increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • carbinoxamine

                  carbinoxamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • carisoprodol

                  carisoprodol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chloral hydrate

                  chloral hydrate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlordiazepoxide

                  chlordiazepoxide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlorpheniramine

                  chlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlorpromazine

                  chlorpromazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlorpropamide

                  ketotifen, ophthalmic, chlorpropamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • chlorzoxazone

                  chlorzoxazone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cinnarizine

                  cinnarizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clemastine

                  clemastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clomipramine

                  clomipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clonazepam

                  clonazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clorazepate

                  clorazepate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clozapine

                  clozapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • codeine

                  codeine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cyclizine

                  cyclizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cyclobenzaprine

                  cyclobenzaprine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cyproheptadine

                  cyproheptadine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dantrolene

                  dantrolene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • desflurane

                  desflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • desipramine

                  desipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dexchlorpheniramine

                  dexchlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dexfenfluramine

                  ketotifen, ophthalmic increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dexmedetomidine

                  dexmedetomidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dexmethylphenidate

                  ketotifen, ophthalmic increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dextroamphetamine

                  ketotifen, ophthalmic increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dextromoramide

                  dextromoramide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diamorphine

                  diamorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diazepam

                  diazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diethylpropion

                  ketotifen, ophthalmic increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • difenoxin hcl

                  difenoxin hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dimenhydrinate

                  dimenhydrinate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diphenhydramine

                  diphenhydramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diphenoxylate hcl

                  diphenoxylate hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dipipanone

                  dipipanone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dobutamine

                  ketotifen, ophthalmic increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dopamine

                  ketotifen, ophthalmic increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dopexamine

                  ketotifen, ophthalmic increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • doxepin

                  doxepin and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • doxylamine

                  doxylamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • droperidol

                  droperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • ephedrine

                  ketotifen, ophthalmic increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • epinephrine

                  ketotifen, ophthalmic increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • epinephrine racemic

                  ketotifen, ophthalmic increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • estazolam

                  estazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • ethanol

                  ethanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • etomidate

                  etomidate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • fenfluramine

                  ketotifen, ophthalmic increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • fluphenazine

                  fluphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • flurazepam

                  flurazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • formoterol

                  ketotifen, ophthalmic increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • glimepiride

                  ketotifen, ophthalmic, glimepiride. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • glipizide

                  ketotifen, ophthalmic, glipizide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • glyburide

                  ketotifen, ophthalmic, glyburide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • haloperidol

                  haloperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • hydromorphone

                  hydromorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • hydroxyzine

                  hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • iloperidone

                  iloperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • imipramine

                  imipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • insulin aspart

                  ketotifen, ophthalmic, insulin aspart. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin detemir

                  ketotifen, ophthalmic, insulin detemir. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin glargine

                  ketotifen, ophthalmic, insulin glargine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin glulisine

                  ketotifen, ophthalmic, insulin glulisine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin lispro

                  ketotifen, ophthalmic, insulin lispro. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin NPH

                  ketotifen, ophthalmic, insulin NPH. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin regular human

                  ketotifen, ophthalmic, insulin regular human. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • isoproterenol

                  ketotifen, ophthalmic increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ketamine

                  ketamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • levalbuterol

                  ketotifen, ophthalmic increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • levorphanol

                  levorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lisdexamfetamine

                  ketotifen, ophthalmic increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • lofepramine

                  lofepramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lofexidine

                  ketotifen, ophthalmic and lofexidine both increase sedation. Use Caution/Monitor.

                • loprazolam

                  loprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lorazepam

                  lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lormetazepam

                  lormetazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • loxapine

                  loxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • loxapine inhaled

                  loxapine inhaled and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lurasidone

                  lurasidone, ketotifen, ophthalmic. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                • maprotiline

                  maprotiline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • marijuana

                  ketotifen, ophthalmic and marijuana both increase sedation. Use Caution/Monitor.

                • melatonin

                  ketotifen, ophthalmic and melatonin both increase sedation. Use Caution/Monitor.

                • meperidine

                  meperidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • meprobamate

                  ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.

                • metaproterenol

                  ketotifen, ophthalmic increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • metaxalone

                  metaxalone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • metformin

                  ketotifen, ophthalmic, metformin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • methadone

                  methadone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • methamphetamine

                  ketotifen, ophthalmic increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • methocarbamol

                  methocarbamol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • methylenedioxymethamphetamine

                  ketotifen, ophthalmic increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • midazolam

                  midazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • midodrine

                  ketotifen, ophthalmic increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • miglitol

                  ketotifen, ophthalmic, miglitol. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • mirtazapine

                  ketotifen, ophthalmic and mirtazapine both increase sedation. Use Caution/Monitor.

                • modafinil

                  ketotifen, ophthalmic increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • morphine

                  morphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • motherwort

                  ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.

                • moxonidine

                  ketotifen, ophthalmic and moxonidine both increase sedation. Use Caution/Monitor.

                • nabilone

                  ketotifen, ophthalmic and nabilone both increase sedation. Use Caution/Monitor.

                • nalbuphine

                  nalbuphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • nateglinide

                  ketotifen, ophthalmic, nateglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • norepinephrine

                  ketotifen, ophthalmic increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nortriptyline

                  nortriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • olanzapine

                  olanzapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • opium tincture

                  opium tincture and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • orphenadrine

                  orphenadrine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • oxazepam

                  oxazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • oxycodone

                  oxycodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • oxymorphone

                  oxymorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • paliperidone

                  paliperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • papaveretum

                  papaveretum and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • papaverine

                  ketotifen, ophthalmic and papaverine both increase sedation. Use Caution/Monitor.

                • pentazocine

                  pentazocine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • pentobarbital

                  pentobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • perphenazine

                  perphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • phendimetrazine

                  ketotifen, ophthalmic increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenobarbital

                  phenobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • phentermine

                  ketotifen, ophthalmic increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenylephrine

                  ketotifen, ophthalmic increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenylephrine PO

                  ketotifen, ophthalmic increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                • pholcodine

                  ketotifen, ophthalmic and pholcodine both increase sedation. Use Caution/Monitor.

                • pimozide

                  pimozide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • pioglitazone

                  ketotifen, ophthalmic, pioglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • pirbuterol

                  ketotifen, ophthalmic increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • primidone

                  primidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • prochlorperazine

                  prochlorperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • promethazine

                  promethazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • propofol

                  propofol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • propylhexedrine

                  ketotifen, ophthalmic increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • protriptyline

                  protriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • quazepam

                  quazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • quetiapine

                  quetiapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • ramelteon

                  ketotifen, ophthalmic and ramelteon both increase sedation. Use Caution/Monitor.

                • repaglinide

                  ketotifen, ophthalmic, repaglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • risperidone

                  risperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • rosiglitazone

                  ketotifen, ophthalmic, rosiglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • rotigotine

                  ketotifen, ophthalmic and rotigotine both increase sedation. Use Caution/Monitor.

                • salmeterol

                  ketotifen, ophthalmic increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • saxagliptin

                  ketotifen, ophthalmic, saxagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • scullcap

                  ketotifen, ophthalmic and scullcap both increase sedation. Use Caution/Monitor.

                • secobarbital

                  secobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • sevoflurane

                  sevoflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • shepherd's purse

                  ketotifen, ophthalmic and shepherd's purse both increase sedation. Use Caution/Monitor.

                • sitagliptin

                  ketotifen, ophthalmic, sitagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • sufentanil

                  sufentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • tapentadol

                  tapentadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • temazepam

                  temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • terbutaline

                  ketotifen, ophthalmic increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • thioridazine

                  thioridazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • thiothixene

                  thiothixene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • tolazamide

                  ketotifen, ophthalmic, tolazamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • tolbutamide

                  ketotifen, ophthalmic, tolbutamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • topiramate

                  ketotifen, ophthalmic and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                • tramadol

                  tramadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • trazodone

                  trazodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • triazolam

                  triazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • triclofos

                  triclofos and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • trifluoperazine

                  trifluoperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • trimipramine

                  trimipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • triprolidine

                  triprolidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • vildagliptin

                  ketotifen, ophthalmic, vildagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • xylometazoline

                  ketotifen, ophthalmic increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • yohimbine

                  ketotifen, ophthalmic increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ziconotide

                  ketotifen, ophthalmic and ziconotide both increase sedation. Use Caution/Monitor.

                • ziprasidone

                  ziprasidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                Minor (3)

                • calcium/magnesium/potassium/sodium oxybates

                  ketotifen, ophthalmic, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • eucalyptus

                  eucalyptus and ketotifen, ophthalmic both increase sedation. Minor/Significance Unknown.

                • sage

                  ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Conjunctivitis

                Headache

                Eye pain

                Lacrimation disorder

                Keratitis

                Mydriasis

                Eyelid disorder

                Rhinitis

                Photophobia

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                Warnings

                Contraindications

                Hypersensitivity

                Cautions

                Delay insertion of soft contact lenses for at least 10 min after ketotifen instillation, since benzalkonium chloride preservative may be absorbed by soft lenses; do not wear contact lenses if eyes red

                Contact healthcare provider if symptoms worsen or do not improve within 3 days of initiating therapy

                Solution should not be used if cloudy or change in color

                Not for treatment of contact lens related irritation

                Discontinue use, and contact healthcare provider, if experience eye pain, changes in vision, redness of the eyes, itching worsens or lasts >72 hr

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                Pregnancy & Lactation

                Pregnancy Category: C

                Lactation: Not known if distributed in milk; use caution

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Histamine H1 antagonist and mast cell stabilizer; inhibits vascular permeability and may prevent chemokine induced migration of eosinophils into inflamed conjunctiva

                Pharmacokinetics

                Onset of action: Minutes

                Absorption: Minimal (systemic)

                Duration: 8-12hr

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                Administration

                Ophthalmic Administration

                Remove contact lenses before use

                Wait at least 10 min before reinserting contact lenses after use

                Avoid contamination by not touching tip of container

                Replace cap after each use

                Storage

                Store at 4-25ºC (39-77ºF)

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                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                Zaditor ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                Zaditor ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                ketotifen ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                Allergy Eye (ketotifen)
                -
                0.025 % (0.035 %) drops
                Children's Alaway ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                Eye Itch Relief
                -
                0.025 % (0.035 %) drops
                Eye Itch Relief
                -
                0.025 % (0.035 %) drops
                Eye Itch Relief
                -
                0.025 % (0.035 %) drops
                Alaway ophthalmic (eye)
                -
                0.025 % (0.035 %) drops

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                Patient Handout

                Patient Education
                ketotifen ophthalmic (eye)

                KETOTIFEN - OPHTHALMIC

                (KEE-toe-TYE-fen)

                COMMON BRAND NAME(S): Zaditor

                USES: This medication is used to prevent and treat itching of the eyes caused by allergies (allergic/seasonal conjunctivitis). Ketotifen is an antihistamine for the eye that treats allergic symptoms by blocking a certain natural substance (histamine). It is also a mast cell stabilizer that prevents allergic reactions by reducing the release of natural substances that cause an allergic reaction.

                HOW TO USE: If you are using the over-the-counter product, read all directions on the product package before using this medication. If your doctor has prescribed this medication, use it exactly as directed.Apply 1 drop to the affected eye(s), usually twice a day (every 8 to 12 hours) or as directed by the package instructions or your doctor.Dosage is based on your medical condition and response to treatment.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.Ask your doctor if you can wear contact lenses while you are being treated with this medication. If your doctor says you may continue wearing them, remove them before using the eye drops, and wait at least 10 minutes after each dose before putting in your lenses. Do not use this medication to treat irritation from contact lens wear. Consult your doctor about the use of contact lenses when the eyes are red or irritated.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and apply 1 drop in the lower eyelid. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye.Do not rinse the dropper. Replace the dropper cap after each use, and keep the bottle tightly closed.If you are using another kind of eye medication (drops or ointment), wait at least 5 minutes before applying it. Apply eye drops before eye ointments to allow the eye drops to enter the eye.If your doctor has prescribed this medication, use it regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue to use this medication as prescribed until pollen season is over or you are no longer exposed to the allergic substance, even when allergic symptoms disappear or improve.If your condition lasts or gets worse, if you develop new symptoms, or if you think you have a serious medical problem, get medical help right away. If you are treating yourself with nonprescription ketotifen, consult your doctor if your itching worsens or lasts more than 72 hours. You may need a different medication.

                SIDE EFFECTS: Burning/stinging/irritation of the eye, headache, stuffy/runny nose, bad taste in your mouth, and increased sensitivity to light may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: dry eyes, eye pain, increased redness/swelling of the eye, vision problems.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                PRECAUTIONS: Before using ketotifen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as the preservative benzalkonium chloride in the multi-dose container), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (such as glaucoma).After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.Do not use this medication in children younger than 3 years unless directed by the doctor.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

                DRUG INTERACTIONS: If this drug has been prescribed, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                NOTES: Do not share this medication with others.Avoid allergens (such as pollen, animal dander) and other triggering factors (such as irritants). Cold compresses and lubricating eye drops may decrease eye irritation.

                MISSED DOSE: If you are using this medication on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

                STORAGE: Store between 39-77 degrees F (4-25 degrees C) away from light and moisture. If you are using the single-dose container, discard it after use. Discard unused single-dose containers 4 weeks after you first open the blister pack (or 3 months after opening if you store them in the original carton box). Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                Information last revised April 2022. Copyright(c) 2022 First Databank, Inc.

                IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.