hydrocortisone topical (Rx, OTC)

Brand and Other Names:Westcort, Locoid, more...Aquanil, Calmurid Cream, Cetacort, Claritin Skin Itch Relief, Coraz, CortaGel, Cortaid, Cortate, Cortisone-10 Poison Ivy Relief Pads, Cortisone-10 Quick Shot, Cortizone, Cortoderm, Dermacort, Dermazene Cream, DermiCort, Emo Cort, Hyderm, Hydrocort, HydroSKIN, HydroVal, Hytone, LactiCare, AlaCort, Locoid Lipocream, Massengill, Neosporin Eczema Essentials Anti-Itch Cream, Nutracort, Pediaderm HC, Penecort, Preparation H Anti-Itch Cream, Prevex HC, Proctocort, Proctocream, Sarna HC, Sarnol, Texacort, Timodine, Uniroid HC, AlaScalpt
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical cream

  • 0.1%
  • 0.2%
  • 0.5%
  • 1%
  • 2.5%

topical lotion

  • 0.1%
  • 1%
  • 2%
  • 2.5%

topical gel

  • 1%
  • 10%

topical solution

  • 1%
  • 2.5%

topical ointment

  • 0.2%
  • 0.5%
  • 1%
  • 2.5%

Atopic Dermatitis

Apply thin film to affected area BID

Corticosteroid-responsive Dermatoses

Relief of inflammatory and pruritic manifestations

Hydrocortisone base: q6-12hr

Hydrocortisone acetate: q6-12hr

Hydrocortisone butyrate: q8-12hr

Hydrocortisone valerate: q8-12hr

Dosage Forms & Strengths

topical cream

  • 0.1%
  • 0.2%
  • 0.5%
  • 1%
  • 2.5%

topical lotion

  • 0.5%
  • 1%
  • 2%
  • 2.5%

topical gel

  • 1%

topical solution

  • 1%
  • 2.5%

topical ointment

  • 0.2%
  • 0.5%
  • 1%
  • 2.5%

Corticosteroid-responsive Dermatoses

Relief of inflammatory and pruritic manifestations

Infants, children, and adolescents; products for OTC use are not labeled for use in children <2 years

Hydrocortisone base: q6-12hr

Hydrocortisone acetate: q6-12hr

Hydrocortisone butyrate: q8-12hr

Dosing considerations

  • Limit to the minimum amount necessary for therapeutic efficacy

Atopic Dermatitis

<3 months: Safety and efficacy not established

≥3 months: Apply film to affected area q12hr

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Adverse Effects

Frequency Not Defined

Skin atrophy

Striae

Acneform lesions

Perioral dermatitis

Folliculitis

Itching

Pigmentation changes

HPA suppression (with higher potency used >2 wk)

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Warnings

Contraindications

Underlying infection

Hypersensitivity

Ophthalmic use

Treatment of diaper dermatitis

Cautions

Chronic topical corticosteroid therapy may interfere with growth and development in children

Use lower potency in children; may absorb proportionally larger amounts after topical application and may cause systemic effects

Occlusive dressings, prolonged use, application to large surface areas, or application to denuded skin, may increase percutaneous absorption, which may result in Cushing syndrome, glycosuria, and hyperglycemia

Prolonged use may increase risk of Kaposi's sarcoma

Prolonged use may increase risk of secondary infection, may mask acute infection, limit response to vaccines, and prolong or exacerbate viral infections; avoid exposure to measles or chickenpox while receiving therapy; not for the treatment of ocular herpes simplex, cerebral malaria, fungal infections, or viral hepatitis; observe patients with latent tuberculosis closely; restrict use in active tuberculosis

Acute myopathy reported with high dose corticosteroids, especially patients with neuromuscular transmission disorders

Psychiatric disturbances including euphoria, insomnia, mood swings, and personality changes reported with corticosteroid use

Allergic contact dermatitis may occur; diagnosed as failure to heal rather than exacerbation; discontinue therapy and treat appropriately if it occurs

May suppress hypothalamic-pituitary-adrenal axis, especially in patients receiving high doses for prolonged periods of time and younger children, which may result in adrenal crisis

Anaphylactoid reactions reported in patients receiving corticosteroids

Local desensitization (irritation, redness) reported; discontinue if it occurs

Use caution in patients with diabetes, cardiovascular disease, hepatic impairment, myocardial infarction, myasthenia gravis, osteoporosis, ocular disease, renal impairment, or thyroid disease

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Pregnancy & Lactation

Pregnancy

There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids; corticosteroids generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels; topical corticosteroids should be used during pregnancy only if potential benefits justify potential risk to fetus; should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time

Lactation

Not know whether topical administration could result in sufficient systemic absorption to produce detectable quantities in breast milk; systemically administered corticosteroids are secreted into breast milk in quantities not likely to have deleterious effect on infant; nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Decreases inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes

Inhibits macrophage accumulation in inflamed areas

Reduces leukocyte adhesion to capillary endothelium

Reduces capillary wall permeability and edema formation

Decreases complement components and antagonizes histamine activity and release of kinin from substrates

Reduces fibroblast proliferation, collagen deposition, and subsequent scar tissue formation

Absorption

Percutaneous; extent of absorption in dependent on formulation, epidermal integrity (intact vs abraded), and the use of occlusive dressings

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
Procto-Pak topical
-
1 % cream
Aquanil HC topical
-
1 % lotion
Cortisone (hydrocortisone) topical
-
1 % cream
Scalacort topical
-
2 % lotion
Cortizone-10 Plus topical
-
1 % cream
Cortizone-10 topical
-
1 % lotion
Cortizone-10 topical
-
1 % cream
Cortizone-10 topical
-
1 % gel
Pramosone topical
-
2.5-1 % cream
Pramosone topical
-
2.5-1 % cream
Pramosone topical
-
1-1 % lotion
Pramosone topical
-
1-1 % lotion
Pramosone topical
-
2.5-1 % lotion
Pramosone topical
-
2.5-1 % lotion
Pramosone topical
-
1-1 % cream
Pramosone topical
-
1-1 % cream
hydrocortisone rectal
-
100 mg/60 mL enema
hydrocortisone oral
-
5 mg tablet
hydrocortisone oral
-
20 mg tablet
hydrocortisone oral
-
10 mg tablet
hydrocortisone oral
-
5 mg tablet
hydrocortisone oral
-
10 mg tablet
hydrocortisone oral
-
20 mg tablet
hydrocortisone oral
-
10 mg tablet
hydrocortisone oral
-
20 mg tablet
hydrocortisone oral
-
5 mg tablet
hydrocortisone oral
-
5 mg tablet
ITCH-X topical
-
1-10 % gel
ITCH-X topical
-
1-10 % liquid
Ala-Scalp topical
-
2 % lotion
hydrocortisone topical
-
0.5 % cream
hydrocortisone topical
-
1 % lotion
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
0.5 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
0.5 % cream
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
2.5 % ointment
hydrocortisone topical
-
2.5 % ointment
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
2.5 % lotion
hydrocortisone topical
-
2.5 % lotion
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
2.5 % ointment
hydrocortisone topical
-
2.5 % ointment
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
2.5 % lotion
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
0.5 % ointment
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
1 % ointment
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
2.5 % cream
hydrocortisone topical
-
1 % cream
hydrocortisone topical
-
0.5 % ointment
Texacort topical
-
2.5 % solution
Cortef oral
-
20 mg tablet
Cortef oral
-
10 mg tablet
Cortef oral
-
5 mg tablet
Anusol-HC rectal
-
25 mg suppos
Anusol-HC rectal
-
25 mg suppos
Scalpicin Anti-Itch topical
-
1 % solution
Procto-Med HC topical
-
2.5 % cream
Anusol-HC topical
-
2.5 % cream
Proctosol HC topical
-
2.5 % cream
Proctocort topical
-
1 % cream
Cortenema rectal
-
100 mg/60 mL enema
Cortenema rectal
-
100 mg/60 mL enema
Proctozone-HC topical
-
2.5 % cream
Proctozone-HC topical
-
2.5 % cream
Cortaid topical
-
1 % cream

Copyright © 2010 First DataBank, Inc.

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Patient Handout

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Patient Education
hydrocortisone topical

HYDROCORTISONE CREAM, OINTMENT- RECTAL

(HYE-droe-KOR-ti-sone)

COMMON BRAND NAME(S): Anusol-HC, Proctocream-HC, Proctosol HC

USES: This medication is used to treat minor pain, itching, swelling, and discomfort caused by hemorrhoids and other problems of the anal area (e.g., anal fissures, itching). Hydrocortisone is a corticosteroid that reduces redness, itching, and swelling.

HOW TO USE: Before use, clean the affected area with mild soap and water, rinse well, and pat dry.To apply this product inside the anus, use the applicator tip/cap/nozzle, following all instructions in the product package, or use as directed by your doctor. Fill the applicator with medication from the container as directed. Gently insert the applicator tip just 1/2 to 1 inch (1.5 to 2.5 centimeters) inside the anus and apply in and around the anal opening as directed. Do not insert your finger or any part of the container into the anus, and do not insert the applicator tip/nozzle more than 1/2 to 1 inch (1.5 to 2.5 centimeters) inside the anus. Do not use your finger to apply this medication inside the anus. If you are using a single-use tube and applicator, discard after one use.To apply the product to the outside of the anus only, use your finger to apply a small amount of cream or ointment to the affected area and rub in gently.Do not cover the area with plastic or waterproof bandages unless directed to do so by your doctor. Covering the treated area may increase the absorption of the medication through the skin. This may improve how well the drug works, but it may also increase the risk of side effects.Wash hands immediately after use. Avoid getting the product in your eyes, nose, ears or mouth. If the medication gets in these areas, rinse the area immediately with clean water.This product is usually used 2 to 4 times daily, or after each bowel movement, or as directed by your doctor. Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.Do not use more of this product, use it more often, or keep using it longer than prescribed by your doctor. If you have been using this medication for a long time or in high doses, do not suddenly stop using it without your doctor's approval. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.Inform your doctor if your condition does not improve or if it worsens after 1 to 2 weeks.

SIDE EFFECTS: Redness, burning, or itching at the application site may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: rectal bleeding, change in skin appearance (e.g., color, thickness), skin redness/tenderness/pus or other signs of infection, signs of serious infection (e.g., fever, persistent sore throat).Rarely, it is possible this medication will be absorbed into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children and people who use this medication for a long time. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this product, tell your doctor or pharmacist if you are allergic to hydrocortisone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, eye problems, infections (especially rectal sores/infections), liver disease, stomach/intestinal problems.Rarely, using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.Caution is advised when using this drug in children. Do not use this product over a large area or use tight-fitting diapers/plastic pants unless directed by your doctor.Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. See the doctor regularly so your child's height can be checked.During pregnancy, this medication should be used only when clearly needed. It should not be used for long periods of time or in large amounts. Discuss the risks and benefits with your doctor.It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: other corticosteroids/immunosuppressants (e.g., prednisone), other rectal products.

OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Laboratory and/or medical tests (e.g., cortisol levels) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in that case.

MISSED DOSE: If you miss a dose, use it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature. Do not refrigerate. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.