benzonatate (Rx)

Brand and Other Names:Tessalon, Tessalon Perles, more...Zonatuss
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 100mg
  • 150mg
  • 200mg

Cough

100 mg, 150 mg, 200 mg PO q8hr; 600 mg/day maximum

Administration

  • Swallow whole; do not chew

Dosage Forms & Strengths

capsule

  • 100mg
  • 150mg
  • 200mg

<10 years

Safety and efficacy not established

>10 years

Cough: 100 mg, 150 mg, 200 mg PO q8hr; 600 mg/day maximum

Administration

  • Swallow whole; do not chew
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Adverse Effects

Frequency Not Defined

Hypersensitivity reaction; bronchospasm, laryngospasm, cardiovascular collapse possibly related to local anesthesia from chewing or sucking the capsule or perle

Chest numbness

Chilly sensation

Confusion

Constipation

Dizziness

GI upset

Hallucinations

Headache

Nasal congestion

Nausea

Pruritus

Sedation

Skin eruptions

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Warnings

Contraindications

Hypersensitivity to benzonatate and related compounds (tetracaine-type topical anesthetics)

Cautions

Keep out of reach of children

Severe hypersensitivity reactions (bronchospasm, cardiovascular collapse) reported with therapy (possibly related to sucking or chewing the capsule)

Deliberate or accidental overdose has resulted in death, particularly in children

Isolated cases of abnormal behavior (mental confusion and visual hallucinations) reported

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Pregnancy & Lactation

Pregnancy category: C

Lactation: Excretion in milk unknown; use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Nonnarcotic antitussive; local anesthetic effect anesthetizes stretch receptors in respiratory passages and lungs

Absorption

Onset: 15-20 min

Duration: 3-8 hr

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
benzonatate oral
-
200 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
150 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
200 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
150 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
100 mg capsule
benzonatate oral
-
100 mg capsule

Copyright © 2010 First DataBank, Inc.

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Patient Handout

Patient Education
benzonatate oral

BENZONATATE- ORAL

(ben-ZOE-na-tate)

COMMON BRAND NAME(S): Tessalon Perle, Zonatuss

USES: This medication is used to treat coughs caused by the common cold and other breathing problems (e.g., pneumonia, bronchitis, emphysema, asthma). It works by reducing the reflex in the lungs that causes the urge to cough.Use of this medication is not recommended in children younger than 10 years. Discuss the risks and benefits with your doctor.

HOW TO USE: Take this medication by mouth with or without food, usually 3 times daily as needed or as directed by your doctor.Swallow this medication whole. Do not chew, suck, or dissolve this medication in your mouth. Doing so will cause a loss of feeling in your mouth/throat and may cause choking or a severe allergic reaction. (See also Side Effects section.) Do not eat or drink until the numbness goes away. Get medical help right away if the numbness persists or worsens.Dosage is based on your medical condition and response to therapy. Do not take more than 200 milligrams at one time. Taking more benzonatate than prescribed will not make your cough go away faster but may result in serious side effects.Tell your doctor if your condition persists or worsens.

SIDE EFFECTS: Drowsiness, dizziness, headache, nausea, stomach upset, constipation, and stuffy nose may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes, loss of feeling in the chest, burning in the eyes.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. The possibility of an allergic reaction may increase if you chew, suck, or dissolve this medication in your mouth. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, fainting.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking benzonatate, tell your doctor or pharmacist if you are allergic to it; or to certain anesthetic agents (e.g., procaine, tetracaine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, or if a child accidentally swallows this medication, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: restlessness, shaking (tremors), seizures, inability to wake up (coma).

NOTES: Do not share this medication with others.

MISSED DOSE: If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Always store benzonatate in a child-resistant container. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.