tebentafusp (Pending FDA Approval)

Brand and Other Names:
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Dosing & Uses

Uveal Melanoma

Pending FDA approval for treatment of HLA-A*02:01-positive metastatic uveal melanoma (mUM)



Mechanism of Action

Bispecific protein comprised of a soluble T-cell receptor fused to an anti-CD3 immune-effector function that specifically targets gp100, a lineage antigen expressed in melanocytes and melanoma

Immune-mobilizing monoclonal T-cell receptors (TCRs) against cancer (ImmTAC) molecules bind cells that present a peptide derived from an antigen of interest, and recruit T-cells to lyse the target cells; to achieve this, ImmTAC molecules are composed of a TCR targeting domain and a single-chain variable fragment (scFv) anti-CD3 effector domain

The TCR targeting domain binds peptides presented on the cell surface as a human leukocyte antigen (HLA)-peptide (pHLA) complex, while the anti-CD3 effector domain engages and activates CD3+ cells



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