sodium lactate (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

infusion solution

  • 5 mEq/mL (560 mg/mL)

Alkalinizing Agent

As directed by physician (based on severity of metabolic acidosis)

Dosage Forms & Strengths

infusion solution

  • 500mL
  • 1000mL

Alkalinizing Agent

As directed by physician (based on severity of metabolic acidosis)

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Interactions

Interaction Checker

and sodium lactate

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (9)

                • bearberry

                  sodium lactate will increase the level or effect of bearberry by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • benzphetamine

                  sodium lactate will increase the level or effect of benzphetamine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • dextroamphetamine

                  sodium lactate will increase the level or effect of dextroamphetamine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • ephedrine

                  sodium lactate will increase the level or effect of ephedrine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • flecainide

                  sodium lactate will increase the level or effect of flecainide by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • memantine

                  sodium lactate will increase the level or effect of memantine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • mexiletine

                  sodium lactate will increase the level or effect of mexiletine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • pseudoephedrine

                  sodium lactate will increase the level or effect of pseudoephedrine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                • quinidine

                  sodium lactate will increase the level or effect of quinidine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.

                Minor (0)

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                  Adverse Effects

                  Frequency Not Defined

                  Febrile response

                  Injection site infections

                  Phlebitis

                  Thrombosis

                  Extravasation

                  Hypervolemia

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                  Warnings

                  Contraindications

                  Not for lactic acidosis

                  Hypernatremia or fluid retention

                  CHF, shock, respiratory alkalosis or other conditions that increase lactate

                  Cautions

                  Significant hypokalemia may occur

                  No advantage over sodium bicarbonate and is contraindicated in the treatment of lactic acidosis

                  Avoid rapid administration and overdosage

                  Excess administration may result in metabolic alkalosis

                  Severe renal impairment, edema with sodium retention

                  Not for correcting severe acidotic states

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: use caution

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Lactate is converted into bicarbonate

                  Pharmacokinetics

                  Metabolism: lactate is converted in the liver into bicarbonate

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                  Administration

                  IV Administration

                  NMT 300 mL/hr in adults

                  Do not use plastic containers in series connections

                  Use only non-vented set or vented set with vent closed

                  IV Incompatibilities

                  Additive: Na-bicarbonate

                  Storage

                  Store at 40°C or less

                  Protect from extreme heat & freezing

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                  Images

                  No images available for this drug.
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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Formulary

                  FormularyPatient Discounts

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                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.