octreotide (Antidote) (Rx)

Brand and Other Names:Sandostatin (Antidote)
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable

  • 50mcg/mL
  • 100mcg/mL
  • 200mcg/mL
  • 500mcg/mL
  • 1000mcg/mL

Sulfonylurea Overdose

Used for sulfonylurea overdoses when more than 1-2 boluses of D50W are ineffective to control hypoglycemia (will be "glucose sparing")

50-100 mcg SC/IV BID/TID, adjust according to blood glucose

For IV, dilute in 50 mL 0.9% NaCl or D5W and infuse over 15-30 minutes (may be given IV push over 3 minutes)

Dosage Forms & Strengths

injectable

  • 50mcg/mL
  • 100mcg/mL
  • 200mcg/mL
  • 500mcg/mL
  • 1000mcg/mL

Sulfonylurea Overdose

Used for sulfonylurea overdoses when more than 1-2 boluses of D50W are ineffective to control hypoglycemia (will be "glucose sparing")

Not well-established

1 mcg/kg SC q12hr OR 4-5 mcg/kg/day divided QID SC  

Severe refractory cases, start continuous IV infusion at 15 ng/kg/min and titrate to response

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Interactions

Interaction Checker

and octreotide (Antidote)

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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            Contraindicated (9)

            • arsenic trioxide

              arsenic trioxide and octreotide (Antidote) both increase QTc interval. Contraindicated.

            • disopyramide

              disopyramide and octreotide (Antidote) both increase QTc interval. Contraindicated.

            • ibutilide

              ibutilide and octreotide (Antidote) both increase QTc interval. Contraindicated.

            • indapamide

              indapamide and octreotide (Antidote) both increase QTc interval. Contraindicated.

            • pentamidine

              octreotide (Antidote) and pentamidine both increase QTc interval. Contraindicated.

            • pimozide

              octreotide (Antidote) and pimozide both increase QTc interval. Contraindicated.

            • procainamide

              octreotide (Antidote) and procainamide both increase QTc interval. Contraindicated.

            • quinidine

              quinidine and octreotide (Antidote) both increase QTc interval. Contraindicated.

            • sotalol

              octreotide (Antidote) and sotalol both increase QTc interval. Contraindicated.

            Serious - Use Alternative (41)

            • amiodarone

              amiodarone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • amitriptyline

              amitriptyline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • amoxapine

              amoxapine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • artemether/lumefantrine

              artemether/lumefantrine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • chlorpromazine

              chlorpromazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • clarithromycin

              clarithromycin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • clomipramine

              clomipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • desipramine

              desipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • dofetilide

              dofetilide and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • doxepin

              doxepin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • dronedarone

              dronedarone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • droperidol

              droperidol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • epinephrine

              epinephrine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • epinephrine racemic

              epinephrine racemic and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • erythromycin base

              erythromycin base and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • erythromycin ethylsuccinate

              erythromycin ethylsuccinate and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • erythromycin lactobionate

              erythromycin lactobionate and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • erythromycin stearate

              erythromycin stearate and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • fluconazole

              fluconazole and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • fluphenazine

              fluphenazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • formoterol

              formoterol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • haloperidol

              haloperidol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • imipramine

              imipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • ketoconazole

              ketoconazole and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • lofepramine

              lofepramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • lumefantrine

              lumefantrine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • maprotiline

              maprotiline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • mefloquine

              mefloquine increases toxicity of octreotide (Antidote) by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.

            • moxifloxacin

              moxifloxacin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • nilotinib

              nilotinib and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • nortriptyline

              nortriptyline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • perphenazine

              perphenazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • prochlorperazine

              prochlorperazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • promazine

              promazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • promethazine

              promethazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • protriptyline

              protriptyline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • thioridazine

              thioridazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • trazodone

              trazodone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • trifluoperazine

              trifluoperazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • trimipramine

              trimipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.

            • ziprasidone

              octreotide (Antidote) and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.

            Monitor Closely (27)

            • azithromycin

              azithromycin and octreotide (Antidote) both increase QTc interval. Use Caution/Monitor.

            • bedaquiline

              octreotide (Antidote) and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closely

            • cyclosporine

              octreotide (Antidote) decreases levels of cyclosporine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

            • dasatinib

              dasatinib and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • dolasetron

              dolasetron and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • flecainide

              flecainide and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • fluoxetine

              fluoxetine and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • fluvoxamine

              fluvoxamine and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • foscarnet

              foscarnet and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • iloperidone

              iloperidone and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • lapatinib

              lapatinib and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • levofloxacin

              levofloxacin and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • methadone

              methadone and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • ofloxacin

              octreotide (Antidote) and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.

            • paliperidone

              octreotide (Antidote) and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely.

            • paroxetine

              octreotide (Antidote) and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.

            • pazopanib

              octreotide (Antidote) and pazopanib both increase QTc interval. Use Caution/Monitor.

            • posaconazole

              octreotide (Antidote) and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.

            • ranolazine

              octreotide (Antidote) and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.

            • risperidone

              octreotide (Antidote) and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.

            • romidepsin

              octreotide (Antidote) and romidepsin both increase QTc interval. Modify Therapy/Monitor Closely.

            • sulfamethoxazole

              sulfamethoxazole and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.

            • telavancin

              octreotide (Antidote) and telavancin both increase QTc interval. Modify Therapy/Monitor Closely.

            • trimethoprim

              octreotide (Antidote) and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely.

            • tropisetron

              octreotide (Antidote) and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely.

            • venlafaxine

              octreotide (Antidote) and venlafaxine both increase QTc interval. Modify Therapy/Monitor Closely.

            • voriconazole

              octreotide (Antidote) and voriconazole both increase QTc interval. Modify Therapy/Monitor Closely.

            Minor (3)

            • cyanocobalamin

              octreotide (Antidote) decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

            • food

              food decreases levels of octreotide (Antidote) by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Particularly high fat food.

            • methadone

              octreotide (Antidote) decreases levels of methadone by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

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            Adverse Effects

            Frequency Not Defined

            Conduction abnormalities

            CHF

            Dizziness

            Fatigue

            Headache

            Diarrhea

            Nausea

            Pain at injection site

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            Pregnancy & Lactation

            Pregnancy Category: B

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            An analogue of somatostatin

            Antagonizes pancreatic insulin release

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            Images

            BRAND FORM. UNIT PRICE PILL IMAGE
            Sandostatin injection
            -
            100 mcg/mL solution
            Sandostatin injection
            -
            50 mcg/mL solution
            Sandostatin injection
            -
            500 mcg/mL solution
            Mycapssa oral
            -
            20 mg capsule
            octreotide acetate injection
            -
            1,000 mcg/mL vial
            octreotide acetate injection
            -
            50 mcg/mL vial
            octreotide acetate injection
            -
            100 mcg/mL vial
            octreotide acetate injection
            -
            500 mcg/mL vial
            octreotide acetate injection
            -
            1,000 mcg/mL vial
            octreotide acetate injection
            -
            1,000 mcg/mL vial
            octreotide acetate injection
            -
            500 mcg/mL solution
            octreotide acetate injection
            -
            200 mcg/mL vial
            octreotide acetate injection
            -
            100 mcg/mL solution
            octreotide acetate injection
            -
            50 mcg/mL solution
            octreotide acetate injection
            -
            50 mcg/mL vial
            octreotide acetate injection
            -
            50 mcg/mL vial
            octreotide acetate injection
            -
            100 mcg/mL vial
            octreotide acetate injection
            -
            500 mcg/mL vial
            octreotide acetate injection
            -
            200 mcg/mL vial
            octreotide acetate injection
            -
            200 mcg/mL vial
            octreotide acetate injection
            -
            50 mcg/mL (1 mL) solution
            octreotide acetate injection
            -
            100 mcg/mL (1 mL) solution
            octreotide acetate injection
            -
            500 mcg/mL (1 mL) solution
            octreotide acetate injection
            -
            200 mcg/mL vial
            octreotide acetate injection
            -
            1,000 mcg/mL vial
            octreotide acetate injection
            -
            500 mcg/mL vial
            octreotide acetate injection
            -
            100 mcg/mL vial
            octreotide acetate injection
            -
            50 mcg/mL vial
            octreotide acetate injection
            -
            50 mcg/mL vial
            octreotide acetate injection
            -
            500 mcg/mL vial
            octreotide acetate injection
            -
            100 mcg/mL vial
            octreotide acetate injection
            -
            50 mcg/mL vial
            octreotide acetate injection
            -
            1,000 mcg/mL vial
            octreotide acetate injection
            -
            200 mcg/mL vial

            Copyright © 2010 First DataBank, Inc.

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            Patient Handout

            Patient Education
            octreotide acetate injection

            OCTREOTIDE - INJECTION

            (ok-TREE-oh-tide)

            COMMON BRAND NAME(S): Sandostatin

            USES: Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors (such as carcinoid tumors, vasoactive intestinal peptide tumors) that are found usually in the intestines and pancreas. The symptoms occur when these tumors make too much of certain natural substances (hormones). This medication works by blocking the production of these hormones. By decreasing watery diarrhea, octreotide helps to reduce the loss of body fluids and minerals.Octreotide is also used to treat a certain condition (acromegaly) that occurs when the body makes too much of a certain natural substance called growth hormone. Treating acromegaly helps reduce the risk of serious problems such as diabetes and heart disease. Octreotide works by decreasing the amount of growth hormone to normal levels.This drug is not a cure for these conditions. This medication is usually used with other treatment (such as surgery, radiation, other drugs).

            HOW TO USE: This medication is usually given by injection under the skin, usually 2 to 3 times a day or as directed by your doctor. Depending on your condition, it may be given by injection into a vein by a health care professional.If your doctor directs you to inject this medication under the skin yourself, learn all preparation and usage instructions from your health care professional. Learn how to store and discard needles and medical supplies safely. If you have questions, ask your health care professional.Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the location of the injection site each time to avoid problem areas under the skin.Dosage is based on your medical condition and response to treatment.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Tell your doctor if your condition does not improve or if it worsens.

            SIDE EFFECTS: Nausea, vomiting, loose/oily stools, constipation, stomach upset, gas, bloating, dizziness, or headache may occur. Pain and irritation at the injection site may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: signs of gallbladder/liver problems (such as fever, stomach/abdominal pain, severe nausea/vomiting, yellowing eyes/skin, unexplained pain in the back/right shoulder), signs of underactive thyroid (such as unexplained weight gain, cold intolerance, slow heartbeat, severe constipation, unusual/extreme tiredness, growth/lump/swelling on the front of the neck), worsening heart condition symptoms (such as trouble breathing, slow/fast/irregular heartbeat), numbness/tingling of the arms/legs.This medication may rarely cause changes in blood sugar, especially if you have diabetes. Symptoms of high blood sugar include increased thirst and urination. Symptoms of low blood sugar include nervousness, shakiness, sweating, fast heartbeat, and hunger. Follow your doctor's instructions to treat low blood sugar (for example, by eating a quick source of sugar such as glucose gel/tablets, table sugar, or honey, or drinking fruit juice or non-diet soda). Tell your doctor right away if you experience symptoms of high or low blood sugar while using this medication. Monitor your blood sugar levels as directed by your doctor. Your doctor may need to adjust your diabetes medications.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

            PRECAUTIONS: Before using octreotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (such as cirrhosis), diabetes, thyroid problems, gallbladder problems (such as gallstones), heart problems (such as heart failure), nutrition problems (such as decreased fat absorption, vitamin B12 deficiency).This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).If used for a long time (such as longer than 1 year), this medication may slow a child's growth rate. However, the growth rate catches up after treatment with the drug is stopped. Consult your doctor for more information.This medication may restore the normal ability to become pregnant in females with acromegaly who have infertility. Females of childbearing age should discuss reliable forms of birth control with the doctor. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

            DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (such as prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

            OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

            NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood glucose tests, thyroid function tests, hormone levels, vitamin B12 levels) should be done before you start using this medication and while you are using it. Keep all medical and lab appointments. Consult your doctor for more details.

            MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

            STORAGE: Store this medication in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light. Allow the medication to come to room temperature before using. This medication is good for 2 weeks if stored at room temperature between 68-86 degrees F (20-30 degrees C) away from light. Multi-use vials should be discarded 2 weeks after opening. Ampules should be opened just before each dose, and any unused portion should be discarded. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

            Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

            IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.