Rimso 50, (dimethyl sulfoxide) dosing, indications, interactions, adverse effects, and more

Sections

Sections dimethyl sulfoxide
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

intravesicular solution

Interstitial Cystitis

Instill 50 mL intravesicularly into bladder and allow to remain for 15 minutes; repeat q2Weeks until symptom relief

After maximum symptomatic relief achieved, may decrease frequency

Safety and efficacy not established

Frequency Not Defined

Garlic breath

Garlic taste

Chemical cystitis, transient

Abnormal body odor

Pain following administration of agent (Moderate to Severe)

Anaphylactoid reaction (rare)

Contraindications

None listed by the manufacturer

Cautions

Urinary tract malignancy

Risks of: anaphylactic reactions; transient chemical cystitis

Potential risk of eye lens opacity

Not for IV or IM use; intravesicular use only

Use caution in patients with urinary tract malignancy (vasodilatory effects may be harmful)

Pregnancy & Lactation

Pregnancy Category: C

Lactation: Excretion in milk unknown; use with caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: oxidized to dimethylsulfone & reduced to dimethylsulfide

Excretion: feces, urine, breath, sweat

Mechanism of Action

Analgesic & antiinflammatory; may inhibit free radical formation

Has anti-inflammatory, analgesic, mast cell inhibition, and muscle relaxing effects

Pharmacokinetics

Absorption: Well absorbed

Metabolism: Oxidation to dimethyl

Excretion: Urine, feces, skin, lungs

Distribution: Rapidly penetrates tissues

Metabolism: Oxidized to dimethylsulfone & reduced to dimethylsulfide

BRAND	FORM.	UNIT PRICE	PILL IMAGE
Rimso-50 intravesical -	50 % solution
Cryoserv -	99 % vial
Cryoserv -	99 % vial

Patient Handout

Select a drug:

DIMETHYL SULFOXIDE SOLUTION - IRRIGATION

(DI-meth-ill SULF-ox-ide)

COMMON BRAND NAME(S): Rimso-50

USES: This medication is used to treat a certain bladder condition (interstitial cystitis). Dimethyl sulfoxide is also known as DMSO. It is believed to reduce swelling and pain due to interstitial cystitis and may improve blood supply to the treated area.

HOW TO USE: This medication is placed into the bladder, usually through a tube (catheter device). The medication is kept in the bladder for at least 15 minutes or as directed by your doctor. After this time, urinate to remove the drug from the bladder.This treatment is usually repeated every two weeks until relief of symptoms occurs. Follow your doctor's instructions carefully.This medication is not meant to be given in any other way such as injection into a vein, muscle, or joint. Also, DMSO should not be placed into the bladder at the same time as any other medications.Inform your doctor if your condition lasts or gets worse.

SIDE EFFECTS: Bladder pain and discomfort may occur. A garlic-like taste in the mouth may be noticed within minutes of placing this medication in the bladder. This taste may last several hours, and an odor on the breath or from the skin may be noticed for up to 3 days following use of this medication. If any of these effects last or get worse, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: vision changes.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using dimethyl sulfoxide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: cancer of the urinary tract.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medicine may be harmful if swallowed.

NOTES: Do not share this medication with others.Lab and/or medical tests (such as liver/kidney function, complete blood counts, eye exams) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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