Dosing & Uses
Dosage Forms & Strengths
pyrethrins/piperonyl butoxide
lotion
- 0.3%/2%
gel
- 0.3%/3%
shampoo
- 0.33%/4%
Treatment of Head, Body, Pubic Lice
Apply to completelly wet infested areas, leave on 10 min & wash with large amount of warm water
Use fine toothed comb to remove lice and egg from hair
Shampoo hair to restore body and luster
Do not exceed 2 consecutive applications within 24 hr
Retreat in 7-10 days
Amount to apply varies: See package insert
Dosage Forms & Strengths
pyrethrins/piperonyl butoxide
lotion
- 0.3%/2%
gel
- 0.3%/3%
shampoo
- 0.33%/4%
Treatment of Head, Body Lice
Apply to completelly wet infested areas, leave on 10 min & wash with large amount of warm water
Use fine toothed comb to remove lice and egg from hair
Shampoo hair to restore body and luster
Do not exceed 2 consecutive applications within 24 hr
Retreat in 7-10 days
Amount to apply varies: See package insert
Adverse Effects
Frequency Not Defined
Erythema
Pruritus
Burning
Stinging
Urticaria
Edema
Slight corneal erosion
Warnings
Contraindications
Hypersensitivity to product, ragweed (Asteraceae family plants) hypersensitivity
Cautions
For external use only
Avoid using near eye or use in eyelashes or eyebrow
Avoid contact with mucosal tissues (oral, nasal, genitalia)
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Lactating women may receive therapy
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Following absorption through the chitinous exoskeleton of arthropods, pyrethrins stimulate the nervous system, apparently by competitively interfering with cationic conductances in the lipid layer of nerve cells, thereby blocking nerve impulse transmissions
Piperonyl butoxide has little or no insecticidal activity but potentiates that of pyrethrins by inhibiting the hydrolytic enzymes responsible for pyrethrins' metabolism in arthropods
Pharmacokinetics
Absorbed: Pyrethrins are absorbed through intact skin when applied topically
Piperonyl butoxide reportedly is poorly absorbed through intact skin when applied topically
Onset of action: 30 min
