Dosing & Uses
Anal Cancer
Pending FDA approval for locally advanced or metastatic squamous cell carcinoma of the anal canal (SCAC) that has progressed on, or are intolerant to platinum-based chemotherapy
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Pharmacology
Mechanism of Action
Monoclonal antibody that targets checkpoint inhibitor PD-1 (programmed death 1) and blocks its interaction with PD-L1 and PD-L2, releasing the PD-1 pathway-mediated inhibition of the immune response, including antitumor immune response, thereby decreasing tumor growth
Binding of the PD-1 ligands PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T-cell proliferation and cytokine production
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Images
No images available for this drug.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
