acetohydroxamic acid (Rx)

Brand and Other Names:Lithostat
  • Print

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 250mg

Chronic Urinary Tract Infection

Indicated for chronic UTS caused by urea-splitting organisms

Initial: 12 mg/kg/day PO divided q6 -8hr on empty stomach  

Maintenance: 250 mg PO q6-8hr; not to exceed 1.5 g/day

Renal Impairment

SCr 1.8-2.5 mg/dL [159-221 micromoles/L]: Dose q12hr; not to exceed 1 g/day

SCr >2.5 mg/dL [>221 micromoles/L]: Not recommended

Dosage Forms & Strengths

tablet

  • 250mg

Chronic Urinary Tract Infection

Indicated for chronic UTS caused by urea-splitting organisms

Initial: 10 mg/kg/day PO divided q6-8hr on empty stomach; titrate to patient response  

Chronic Urinary Tract Infection

Indicated for chronic UTS caused by urea-splitting organisms

Initial: 12 mg/kg/day PO divided q6-8hr on empty stomach

Maintenance: 250 mg PO q6-8hr; not to exceed 1.5 g/day

Next:

Interactions

Interaction Checker

and acetohydroxamic acid

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • sodium picosulfate/magnesium oxide/anhydrous citric acid

                  acetohydroxamic acid decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.

                Minor (6)

                • ethanol

                  acetohydroxamic acid, ethanol. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Temporary rash, flushing.

                • ferric maltol

                  acetohydroxamic acid decreases levels of ferric maltol by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ferrous fumarate

                  acetohydroxamic acid decreases levels of ferrous fumarate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ferrous gluconate

                  acetohydroxamic acid decreases levels of ferrous gluconate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ferrous sulfate

                  acetohydroxamic acid decreases levels of ferrous sulfate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                • rose hips

                  acetohydroxamic acid decreases levels of rose hips by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

                Previous
                Next:

                Adverse Effects

                >10%

                Mild headache; first 48 hours (30%)

                Anorexia (20-25%)

                Malaise (20-25%)

                Nausea (20-25%)

                Vomiting (20-25%)

                Anxiety (20%)

                Confused (20%)

                Depression (20%)

                Involuntary quivering (20%)

                Hemolytic anemia (15%)

                <1%

                Alopecia

                Blood clot

                Macular rash

                Phlebitis

                Previous
                Next:

                Warnings

                Contraindications

                Hypersensitivity

                Pts. amenable to definitive surgery & antimicrobial agents, infection by non-urease producing organisms, urinary infections controlled by culture-specific antimicrobials, severe renal impairment (CrCl <20 mL/min &/or serum creatinine>2.5 mg/dL [221 umol/L]), inadequate contraception (females), pregnancy

                Cautions

                Always use with appropriate antimicrobial treatment

                Potential teratogen

                Previous
                Next:

                Pregnancy & Lactation

                Pregnancy Category: X

                Lactation: excretion in breast milk unknown/not recommended

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

                Previous
                Next:

                Pharmacology

                Mechanism of Action

                Inhibits bacterial urease, decreasing ammonia production

                Does not acidify urine or have direct antibacterial effect

                Pharmacokinetics

                Absorption: Well-absorbed

                Peak Plasma Time: 15 min -1 hr

                Excretion: Urine (55% of oral dose unchanged)

                Previous
                Next:

                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                Lithostat oral
                -
                250 mg tablet

                Copyright © 2010 First DataBank, Inc.

                Previous
                Next:

                Patient Handout

                Patient Education
                acetohydroxamic acid oral

                ACETOHYDROXAMIC ACID - ORAL

                (a-SEET-oh-HYE-drox-AM-ik AS-id)

                COMMON BRAND NAME(S): Lithostat

                USES: This medication is used with antibiotics and/or surgery to treat types of bladder infections that are caused by certain bacteria. These bacteria cause the level of ammonia in the urine to become too high. This effect can lead to a certain type of kidney stone (struvite). This medication works by stopping the bacteria from making the ammonia. The decreased levels of ammonia can slow the growth of the kidney stones and make the antibiotic work better on your infection.

                HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using acetohydroxamic acid and each time you get a refill. If you have any questions, consult your doctor or pharmacist.Take this medication by mouth on an empty stomach, usually 3 to 4 times daily or as directed by your doctor.Dosage is based on your medical condition, weight, and response to treatment. Do not take more than 1500 milligrams a day.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Tell your doctor if your condition persists or worsens.

                SIDE EFFECTS: Headache, nausea, vomiting, stomach upset, unusual hair loss, or loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: fast/pounding heartbeat, unusual tiredness, weakness, dark urine, mental/mood changes (e.g., nervousness, depression), shaking (tremor).Tell your doctor right away if any of these rare but very serious side effects occur: pain/redness/swelling of arms or legs, easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat).Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest pain.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                PRECAUTIONS: Before taking acetohydroxamic acid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, blood clots, blood/bone marrow disorders (e.g., anemia), regular alcohol use.Avoid alcoholic beverages while taking this medication because alcohol with acetohydroxamic acid may cause a skin reaction (e.g., flushing, redness, warmth, tingling). The reaction usually appears 30 to 45 minutes after having alcohol and disappears 30 to 60 minutes later.This medication must not be used during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (e.g., condoms, birth control pills) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.This drug may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

                DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: iron-containing products taken by mouth (e.g., supplements, multivitamins).This document does not contain all possible interactions. Before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: loss of appetite, weakness, unusual tiredness, nausea, vomiting, shaking (tremor).

                NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count, liver/kidney function) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

                MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

                STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

                IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

                Previous
                Next:

                Formulary

                FormularyPatient Discounts

                Adding plans allows you to compare formulary status to other drugs in the same class.

                To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                Adding plans allows you to:

                • View the formulary and any restrictions for each plan.
                • Manage and view all your plans together – even plans in different states.
                • Compare formulary status to other drugs in the same class.
                • Access your plan list on any device – mobile or desktop.

                The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                Tier Description
                1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                NC NOT COVERED – Drugs that are not covered by the plan.
                Code Definition
                PA Prior Authorization
                Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                QL Quantity Limits
                Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                ST Step Therapy
                Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                OR Other Restrictions
                Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
                Additional Offers
                Email to Patient

                From:

                To:

                The recipient will receive more details and instructions to access this offer.

                By clicking send, you acknowledge that you have permission to email the recipient with this information.

                Email Forms to Patient

                From:

                To:

                The recipient will receive more details and instructions to access this offer.

                By clicking send, you acknowledge that you have permission to email the recipient with this information.

                Previous
                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.