potassium chloride (Rx)

Brand and Other Names:KDur, Slow K, more...Kaon Cl 10, KCl, K10, Klor-Con M, Klor Con M10, Klor Con M15, Klor Con M20, KlorCon, Klotrix, KTab, MicroK, K8
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 20mEq

tablet, extended-release

  • 8mEq
  • 10mEq
  • 15mEq
  • 20mEq

solution, oral

  • 20mEq/15mL
  • 40mEq/15mL

packet, oral

  • 20mEq

capsules, extended-release

  • 8mEq
  • 10mEq

premix IV in plastic container

  • 10mEq
  • 20mEq
  • 30mEq
  • 40mEq

Hypokalemia

Mild to moderate

  • Capsules or tablets: 40-100 mEq PO qDay in divided doses; single dose not to exceed 25 mEq to minimize GI discomfort
  • Oral solution: 40-100 mEq PO qDay in 2 to 5 divided doses; limit single doses to 40 mEq/dose; not to exceed 200 mEq/24hr
  • Aternatively, 10-20 mEq PO BID/QID (20-80 mEq/day)

Severe hypokalemia

  • 40 mEq PO TID/QID; may also administer 20 mEq PO BID/TID in addition to IV potassium administration with careful monitoring; doses >40 mEq are typically not well tolerated orally, resulting in GI irritation and nausea

Hypokalemia Prophylaxis

20-40 mEq PO qDay or divided BID

Dosing considerations

  • Dosing varies; adjust to serum potassium levels

IV intermittent infusions

≤10 mEq/hr; repeat as needed based on lab values done frequently; central line infusion and continuous ECG monitoring recommended for infusions >10 mEq/hr

10 mEq of potassium chloride increases serum potassium levels by approximately 0.1 mEq/.L

Dosing based on serum potassium

  • 2.5-3.5 mEq/L: 10 mEq/hr maximum infusion rate; 40 mEq/L mazimum concentration; not to exceed 200 mEq dose/24hr
  • <2.5 mEq/L or symptomatic hypokalemia (excluding emergency treatment of cardiac arrest): 40 mEq/hr maximum infusion rate (central line only) in presence of continuous ECG monitoring and frequent lab monitoring; patients may require up to 400 mEq/24hr

Dosing Modifications

Hepatic impairment

  • Patients with cirrhosis should usually be started at low end of dosing range, and serum potassium level should be monitored frequently

Renal impairment

  • Patients with impaired renal function, particularly if patient is on RAAS inhibitors or nonsteroidal anti-inflammatory drugs, should usually be started at low end of dosing range because of potential for development of hyperkalemia; serum potassium level should be monitored frequently; renal function should be assessed periodically

Dosage Forms & Strengths

tablet

  • 20mEq

tablet, extended-release

  • 8mEq
  • 10mEq
  • 15mEq
  • 20mEq

solution, oral

  • 20mEq/15mL
  • 40mEq/15mL

packet, oral

  • 20mEq

capsules, extended-release

  • 8mEq
  • 10mEq

premixed IV in plastic container

  • 10mEq
  • 20mEq
  • 30mEq
  • 40mEq

Hypokalemia prophylaxis

For ongoing drug losses, including diuretic

>1 month: 1-2 mEq/kg qDay of BID; single dose not to exceed usual adult single dose of 20 mEq/dose, although some patients may require a single dose up to 40 mEq/dose or higher based on lab values and ongoing losses  

Hypokalemia

Mild to moderate

  • >1 month: 2-5 mEq/kg PO in divided doses; not to exceed 1-2 mEq/kg as single dose or 20 mEq/kg, whichever is less; consider IV administration if deficit severe or ongoing losses great  

Severe

  • 0.5-1 mEq/kg/dose; not to exceed 40 mEq/dose; infuse at 0.5 mEq/kg/hr; evaluate serum concentrations 1-2 hr after completion of infusion; repeat as necessary based on lab values; severe depletion or ongoing losses may require >200% of normal daily maintenance
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Interactions

Interaction Checker

and potassium chloride

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            Contraindicated (0)

              Serious - Use Alternative (10)

              • amiloride

                amiloride and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug.

              • baloxavir marboxil

                potassium chloride will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.

              • drospirenone

                drospirenone and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug.

              • eplerenone

                potassium chloride, eplerenone. Mechanism: pharmacodynamic synergism. Contraindicated. Hyperkalemia.

              • oxybutynin

                potassium chloride, oxybutynin. Other (see comment). Avoid or Use Alternate Drug. Comment: Patients using drugs with extensive anticholinergic effects should avoid concomitant use with solid oral dosage forms of potassium chloride. May use effervescent potassium preparations as alternatives. .

              • potassium acid phosphate

                potassium acid phosphate and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug.

              • potassium citrate

                potassium chloride and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.

              • potassium phosphates, IV

                potassium chloride and potassium phosphates, IV both increase serum potassium. Avoid or Use Alternate Drug.

              • spironolactone

                spironolactone and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug.

              • triamterene

                triamterene and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug.

              Monitor Closely (108)

              • acebutolol

                acebutolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • aceclofenac

                aceclofenac and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • acemetacin

                acemetacin and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • albuterol

                potassium chloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • arformoterol

                potassium chloride increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • aspirin

                aspirin and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • aspirin rectal

                aspirin rectal and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • aspirin/citric acid/sodium bicarbonate

                aspirin/citric acid/sodium bicarbonate and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • atenolol

                atenolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • benazepril

                benazepril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

                potassium chloride and benazepril both increase serum potassium. Use Caution/Monitor.

              • bendroflumethiazide

                potassium chloride increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • betaxolol

                betaxolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • bisoprolol

                bisoprolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • bumetanide

                potassium chloride increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • canagliflozin

                potassium chloride and canagliflozin both increase serum potassium. Use Caution/Monitor.

              • candesartan

                candesartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • captopril

                captopril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

                potassium chloride increases toxicity of captopril by Mechanism: unspecified interaction mechanism. Modify Therapy/Monitor Closely. Both drugs increase potassium. Monitor potassium.

              • carbenoxolone

                potassium chloride increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • carvedilol

                carvedilol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • celecoxib

                celecoxib and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • celiprolol

                celiprolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • chlorothiazide

                potassium chloride increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • chlorthalidone

                potassium chloride increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • choline magnesium trisalicylate

                choline magnesium trisalicylate and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • cyclopenthiazide

                potassium chloride increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • diclofenac

                diclofenac and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • diflunisal

                diflunisal and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • digoxin

                potassium chloride and digoxin both increase serum potassium. Modify Therapy/Monitor Closely.

              • disopyramide

                potassium chloride increases effects of disopyramide by pharmacodynamic synergism. Use Caution/Monitor. Additive cardiovascular depression.

              • dobutamine

                potassium chloride increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • dopexamine

                potassium chloride increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • enalapril

                enalapril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • ephedrine

                potassium chloride increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • epinephrine

                potassium chloride increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • epinephrine racemic

                potassium chloride increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • eprosartan

                eprosartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • esmolol

                esmolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • ethacrynic acid

                potassium chloride increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • etodolac

                etodolac and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • fenoprofen

                fenoprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • finerenone

                potassium chloride and finerenone both increase serum potassium. Modify Therapy/Monitor Closely. Finerenone dose adjustment based on current serum potassium concentration. Monitor serum potassium and adjust finerenone dose as described in the prescribing information as necessary.

              • flurbiprofen

                flurbiprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • formoterol

                potassium chloride increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • fosinopril

                fosinopril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • furosemide

                potassium chloride increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • gentamicin

                potassium chloride increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • hydrochlorothiazide

                potassium chloride increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • ibuprofen

                ibuprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • ibuprofen IV

                ibuprofen IV and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • imidapril

                imidapril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • indapamide

                potassium chloride increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • indomethacin

                indomethacin and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • irbesartan

                irbesartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • isoproterenol

                potassium chloride increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • ketoprofen

                ketoprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • ketorolac

                ketorolac and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • ketorolac intranasal

                ketorolac intranasal and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • labetalol

                labetalol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • levalbuterol

                potassium chloride increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • lisinopril

                lisinopril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • lornoxicam

                lornoxicam and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • losartan

                losartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • meclofenamate

                meclofenamate and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • mefenamic acid

                mefenamic acid and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • meloxicam

                meloxicam and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • metaproterenol

                potassium chloride increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • methyclothiazide

                potassium chloride increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. .

              • metolazone

                potassium chloride increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • metoprolol

                metoprolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • moexipril

                moexipril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • nabumetone

                nabumetone and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • nadolol

                nadolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • naproxen

                naproxen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • nebivolol

                nebivolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • noni juice

                potassium chloride and noni juice both increase serum potassium. Use Caution/Monitor.

              • norepinephrine

                potassium chloride increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • olmesartan

                olmesartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • oxaprozin

                oxaprozin and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • parecoxib

                parecoxib and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • penbutolol

                penbutolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • perindopril

                perindopril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • pindolol

                pindolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • pirbuterol

                potassium chloride increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • piroxicam

                piroxicam and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • potassium citrate/citric acid

                potassium chloride and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.

              • propranolol

                propranolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • quinapril

                quinapril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • ramipril

                ramipril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • rilpivirine

                potassium chloride decreases levels of rilpivirine by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Coadministration of antacids with rilpivirine may cause significant decreases in rilpivirine plasma concentrations because of increased gastric pH. If antacids must be administered, they should given at least 2 hr before or at least 4 hr after rilpivirine.

              • sacubitril/valsartan

                sacubitril/valsartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • salicylates (non-asa)

                salicylates (non-asa) and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • salmeterol

                potassium chloride increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • salsalate

                salsalate and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • sotalol

                sotalol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • succinylcholine

                potassium chloride and succinylcholine both increase serum potassium. Modify Therapy/Monitor Closely.

              • sulfasalazine

                sulfasalazine and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • sulindac

                sulindac and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • telmisartan

                telmisartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • terbutaline

                potassium chloride increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • timolol

                timolol and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • tolfenamic acid

                tolfenamic acid and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • tolmetin

                tolmetin and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

              • tolvaptan

                potassium chloride and tolvaptan both increase serum potassium. Modify Therapy/Monitor Closely.

              • torsemide

                potassium chloride increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • trandolapril

                trandolapril increases levels of potassium chloride by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • trimethoprim

                trimethoprim and potassium chloride both increase serum potassium. Use Caution/Monitor. Trimethoprim decreases urinary potassium excretion. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia.

              • valsartan

                valsartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

              • voclosporin

                voclosporin and potassium chloride both increase serum potassium. Use Caution/Monitor.

              Minor (29)

              • acarbose

                potassium chloride increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • amphotericin B deoxycholate

                amphotericin B deoxycholate decreases levels of potassium chloride by increasing renal clearance. Minor/Significance Unknown.

              • bisacodyl

                bisacodyl decreases levels of potassium chloride by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • bisacodyl rectal

                bisacodyl rectal decreases levels of potassium chloride by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • cadexomer iodine

                cadexomer iodine increases levels of potassium chloride by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • chlorpropamide

                potassium chloride increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • glimepiride

                potassium chloride increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • glipizide

                potassium chloride increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • glyburide

                potassium chloride increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin aspart

                potassium chloride increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin detemir

                potassium chloride increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin glargine

                potassium chloride increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin glulisine

                potassium chloride increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin lispro

                potassium chloride increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin NPH

                potassium chloride increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin regular human

                potassium chloride increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • iodinated glycerol

                iodinated glycerol increases levels of potassium chloride by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • iodine

                iodine increases levels of potassium chloride by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • metformin

                potassium chloride increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • miglitol

                potassium chloride increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • nateglinide

                potassium chloride increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • pioglitazone

                potassium chloride increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • repaglinide

                potassium chloride increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • rosiglitazone

                potassium chloride increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • saxagliptin

                potassium chloride increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • sitagliptin

                potassium chloride increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • tolazamide

                potassium chloride increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • tolbutamide

                potassium chloride increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • vildagliptin

                potassium chloride increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

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              Adverse Effects

              Frequency Not Defined

              Arrhythmias

              Bleeding

              Diarrhea

              Dyspepsia

              Hyperkalemia

              Nausea

              Rash

              Vomiting

              Postmarketing Reports

              Flatulence

              Abdominal pain/discomfort

              Perforation

              Gastrointestinal obstruction

              Gastrointestinal ulceration

              Gastrointestinal perforation

              Hyponatremia

              Hyponatremic encephalopathy

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              Warnings

              Contraindications

              Hypersensitivity

              Untreated Addison disease

              Hyperkalemia

              Concomitant use with triamterene and amiloride

              Renal failure

              Cautions

              Depending on volume and rate of IV infusion, and patient’s underlying clinical condition, intravenous administration of potassium chloride in sodium chloride can cause electrolyte disturbances such as overhydration/hypervolemia and congested states including central (e.g., pulmonary edema) and peripheral edema

              Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there is sodium retention with edema

              Administration of sodium and potassium in patients with or at risk of severe renal impairment, may result in hypernatremia, hyperkalemia and/or fluid overload; avoid potassium chloride in sodium chloride Injection, USP in patients with severe renal impairment

              If use cannot be avoided, monitor patients with severe renal impairment for development of these adverse reactions

              Rapid correction of hypernatremia is potentially dangerous with risk of serious neurologic complications; excessively rapid correction of hypernatremia is also associated with a risk for serious neurologic complications such as osmotic demyelination syndrome (ODS) with risk of seizures and cerebral edema

              Rapid correction of hyponatremia is potentially dangerous with risk of serious neurologic complications; brain adaptations reducing risk of cerebral edema make the brain vulnerable to injury when chronic hyponatremia is too rapidly corrected, which is known as osmotic demyelination syndrome (ODS); to avoid complications, monitor serum sodium and chloride concentrations, fluid status, acid-base balance, and signs of neurologic complications

              Avoid potassium chloride in sodium chloride injection, USP in patients with or at risk for fluid and/or solute overloading; if use cannot be avoided, monitor fluid balance, electrolyte concentrations and acid base balance as needed and especially during prolonged use

              Solutions containing potassium ions should be used with great care, if at all, in patients with hyperkalemia, severe renal failure, and in conditions in which potassium retention is present

              The risk for hyponatremia is increased in postoperative patients, those with psychogenic polydipsia, and in patients treated with medications that increase risk of hyponatremia (such as diuretics, certain antiepileptic and psychotropic medications)

              Use with care in patients with hypervolemia, renal insufficiency, urinary tract obstruction, or impending or frank cardiac decompensation

              Extraordinary electrolyte losses such as may occur during protracted nasogastric suction, vomiting, diarrhea or gastrointestinal fistula drainage may necessitate additional electrolyte supplementation

              Additional essential electrolytes, minerals and vitamins should be supplied as needed

              Sodium-containing solutions should be administered with caution to patients receiving corticosteroids or corticotropin, or to other salt-retaining patients

              Care should be exercised in administering solutions containing sodium or potassium to patients with renal or cardiovascular insufficiency, with or without congestive heart failure, particularly if they are postoperative or elderly

              Potassium therapy should be guided primarily by serial electrocardiograms, especially in patients receiving digitalis

              Serum potassium levels are not necessarily indicative of tissue potassium levels

              Solutions containing potassium should be used with caution in the presence of cardiac disease, particularly when accompanied by renal disease

              Potassium chloride in sodium chloride may cause hyponatremia; hyponatremia can lead to acute hyponatremic encephalopathy characterized by headache, nausea, seizures, lethargy, and vomiting; patients with brain edema are at particular risk of severe, irreversible and life-threatening brain injury

              Solutions containing dextrose should be used with caution in patients with overt or known subclinical diabetes mellitus, or carbohydrate intolerance for any reason

              Perform continuous cardiac monitoring in patients requiring highly concentrated solutions and perform frequent testing for serum potassium and acid-base balance, especially if they receive digitalis

              Avoid potassium chloride injection in patients with or at risk for hyponatremia; if use cannot be avoided, monitor serum sodium concentrations

              Elderly patients are at increased risk of developing hyponatremia as well as for developing hyponatremic encephalopathy

              Closely monitor plasma electrolyte concentrations in pediatric patients who may have impaired ability to regulate fluids and electrolytes; in very low birth weight infants, excessive or rapid administration of potassium chloride in dextrose injection may result in increased serum osmolality and risk of intracerebral hemorrhage

              Extravasation

              • Care must be taken when infusing concentrated potassium solutions, including potassium chloride injection, to prevent paravenous administration or extravasation; such solutions may be associated with tissue damage, which may be severe and include vascular, nerve, and tendon damage, leading to surgical intervention, including amputation
              • Secondary complications including pulmonary embolism from thrombophlebitis reported as a consequence of tissue damage from potassium chloride

              Oral administration

              • Solid oral dosage forms of potassium chloride can produce ulcerative and/or stenotic lesions of gastrointestinal tract, particularly if drug maintains contact with gastrointestinal mucosa for prolonged periods; consider use of liquid potassium in patients with dysphagia, swallowing disorders, or severe gastrointestinal motility disorders
              • If severe vomiting, abdominal pain, distention, or gastrointestinal bleeding occurs, discontinue therapy and consider possibility of ulceration, obstruction or perforation
              • Oral formulation should not be taken on an empty stomach because of its potential for gastric irritation

              Drug interaction overview

              • Administration of potassium chloride in dextrose injection in patients treated concurrently or recently with other products that can cause hyperkalemia or increase risk of hyperkalemia (eg, potassium-sparing diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers) increases risk of severe and potentially fatal hyperkalemia, in presence of other risk factors for hyperkalemia
              • Avoid use of potassium chloride in 5% dextrose injection in patients receiving such products; if use cannot be avoided, monitor serum potassium concentrations
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              Pregnancy & Lactation

              Pregnancy

              There are no human data related to use of potassium chloride extended-release capsules during pregnancy; animal reproductive studies not conducted; potassium supplementation that does not lead to hyperkalemia is not expected to cause fetal harm

              Appropriate administration of potassium chloride in dextrose injection during pregnancy is not expected to cause adverse developmental outcomes, including congenital malformations; animal reproduction studies have not been conducted with potassium chloride in dextrose injection

              Lactation

              Normal potassium ion content of human milk is about 13 mEq per liter; since oral potassium becomes part of the body potassium pool, as long as body potassium is not excessive, contribution of potassium chloride supplementation should have little or no effect on level in human milk

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Essential in physiologic processes

              Elimination

              Excretion: Urine

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              Administration

              IV Incompatibilities

              Additive: Ampho B

              Y-site: Diazepam

              IV Compatibilities

              Additive: Aminophylline, amiodarone, Ca gluconate, cimetidine, clindamycin, dobutamine, dopamine, erythromycin, furosemide, heparin, hydrocortisone, lidocaine, norepinephrine, Na bicarb, vancomycin, verapamil

              Y-site: Amiodarone, aminophylline, ampicillin, atropine, Ca gluconate, dobutamine, dopamine, epinephrine, esmolol, fentanyl, furosemide, heparin, lidocaine, morphine, norepinephrine, Na bicarb

              Not spec.: Cefazolin, tetracycline

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              K-Tab oral
              -
              10 mEq tablet
              K-Tab oral
              -
              10 mEq tablet
              K-Tab oral
              -
              8 mEq tablet
              K-Tab oral
              -
              20 mEq tablet
              Klor-Con 10 oral
              -
              10 mEq tablet
              potassium chloride intravenous
              -
              2 mEq/mL vial
              potassium chloride intravenous
              -
              2 mEq/mL solution
              potassium chloride intravenous
              -
              2 mEq/mL vial
              potassium chloride intravenous
              -
              2 mEq/mL vial
              potassium chloride intravenous
              -
              2 mEq/mL vial
              potassium chloride intravenous
              -
              2 mEq/mL vial
              potassium chloride intravenous
              -
              2 mEq/mL vial
              potassium chloride intravenous
              -
              2 mEq/mL vial
              Klor-Con M15 oral
              -
              15 mEq tablet
              potassium chloride oral
              -
              10 mEq capsule
              potassium chloride oral
              -
              20 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              8 mEq tablet
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              8 mEq capsule
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              8 mEq capsule
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              8 mEq capsule
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              40 mEq/15 mL liquid
              potassium chloride oral
              -
              10 mEq capsule
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              10 mEq capsule
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              40 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              10 mEq capsule
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              20 mEq/15 mL liquid
              potassium chloride oral
              -
              40 mEq/15 mL liquid
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              20 mEq tablet
              potassium chloride oral
              -
              8 mEq tablet
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              8 mEq capsule
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              8 mEq tablet
              potassium chloride oral
              -
              10 mEq capsule
              potassium chloride oral
              -
              8 mEq capsule
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              20 mEq miscellaneous
              potassium chloride oral
              -
              8 mEq tablet
              potassium chloride oral
              -
              10 mEq capsule
              potassium chloride oral
              -
              10 mEq tablet
              potassium chloride oral
              -
              8 mEq tablet
              Klor-Con M20 oral
              -
              20 mEq tablet
              Klor-Con M10 oral
              -
              10 mEq tablet
              Klor-Con 8 oral
              -
              8 mEq tablet

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Select a drug:
              Patient Education
              potassium chloride intravenous

              NO MONOGRAPH AVAILABLE AT THIS TIME

              USES: Consult your pharmacist.

              HOW TO USE: Consult your pharmacist.

              SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Consult your pharmacist.

              DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

              NOTES: No monograph available at this time.

              MISSED DOSE: Consult your pharmacist.

              STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

              Information last revised July 2016. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.